Evidence map›Paper›PMID 28279183›Full record

ReviewMolecular cancer2017

Circles reshaping the RNA world: from waste to treasure.

Jing Liu, Tian Liu, Xiaman Wang, Aili He

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 250 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed, 4 pooled it
20.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

250 citing papers in PubMed, 4 syntheses or guidelines pooled it, 413 citations in OpenAlex.

  1. Pooled it
  2. Circular RNA as a Potential Biomarker for Melanoma: A Systematic Review.Frontiers in cell and developmental biology · 2021
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Circular RNAs in Organ Fibrosis.Advances in experimental medicine and biology · 2025
    Review

190 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jing LiuDepartment of Clinical Hematology, Second Affiliated Hospital, Xi'an Jiaotong University Health Care Center, 157 West 5 Street, Xi'an, 710004, Shaanxi, People's Republic of China.
Tian LiuDepartment of Clinical Hematology, Second Affiliated Hospital, Xi'an Jiaotong University Health Care Center, 157 West 5 Street, Xi'an, 710004, Shaanxi, People's Republic of China.
Xiaman WangDepartment of Clinical Hematology, Second Affiliated Hospital, Xi'an Jiaotong University Health Care Center, 157 West 5 Street, Xi'an, 710004, Shaanxi, People's Republic of China.
Aili HeDepartment of Clinical Hematology, Second Affiliated Hospital, Xi'an Jiaotong University Health Care Center, 157 West 5 Street, Xi'an, 710004, Shaanxi, People's Republic of China. 15891720403@163.com.
Second Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new type of RNAs was identified from genes traditionally thought to express messenger or linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular RNAs) due to the covalently closed structure. Accumulating studies were performed to explore the expression profile of circRNAs in different cell types and diseases, the outcomes totally changed our view of ncRNAs, which was thought to be junk by-products in the process of gene transcription, and enriched our poor understanding of its underlying functions. The expression profile of circRNAs is tissue-specific and alters across various stages of cell differentiation. The biological function of circRNAs is multi-faceted, involving five main features (sponge effect, post-transcriptional regulation, rolling circle translation, circRNA-derived pseudogenes and splicing interference) and varying differently from the locations, binding sites and acting modes of circRNAs. The regulating role of circRNAs is not isolated but through an enormous complicated network involving mRNAs, miRNAs and proteins. Although most of the potential functions still remain unclear, circRNAs have been proved to be ubiquitous and critical in regulating cellular processes and diseases, especially in cancers, from the laboratory to the clinic. Herein, we review circRNAs' classification, biogenesis and metabolism, their well-studied and anticipated functions, the current understanding of the potential implications of circRNAs in tumorigenesis and cancer targeted therapy.

Indexed as

AnimalsEvolution, MolecularGene Expression RegulationHumansRNARNA, CircularRNA, UntranslatedRNARNA, CircularRNA, UntranslatedBiomarkerCancerCircular RNAmiRNAPost-transcription regulation

Identifiers

PMID28279183
PMCPMC5345220
OpenAlexW2592206889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.