Evidence map›Paper›PMID 28279150›Full record

ArticleBMC infectious diseases2017

ICARES: a real-time automated detection tool for clusters of infectious diseases in the Netherlands.

Geert H Groeneveld, Anton Dalhuijsen, Chakib Kara-Zaïtri, Bob Hamilton, Margot W de Waal, Jaap T van Dissel, Jim E van Steenbergen

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Geert H GroeneveldDepartment of Internal Medicine and Infectious Diseases, Leiden University Medical Center, P.O. box 9600, 2300 RC, Leiden, The Netherlands. g.h.groeneveld@lumc.nl.
Anton DalhuijsenUnit for Infectious Disease Control, Public Health Service Hollands Midden, Leiden, The Netherlands.
Chakib Kara-ZaïtriFaculty of Engineering and Informatics, University of Bradford, Bradford, UK.
Bob HamiltoninFact, Shipley, UK.
Margot W de WaalDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Jaap T van DisselCentre for Infectious Disease Control, National Institute for Public Health and the Environment (Rijksinstituut voor Volksgezondheid en Milieu, RIVM), Bilthoven, The Netherlands.
Jim E van SteenbergenCentre for Infectious Disease Control, National Institute for Public Health and the Environment (Rijksinstituut voor Volksgezondheid en Milieu, RIVM), Bilthoven, The Netherlands.
Leiden University Medical Center · NLNational Institute for Public Health and the Environment · NLGGD Amsterdam · NLShipley Hospital · GBUniversity of Bradford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClusters of infectious diseases are frequently detected late. Real-time, detailed information about an evolving cluster and possible associated conditions is essential for local policy makers, travelers planning to visit the area, and the local population. This is currently illustrated in the Zika virus outbreak.

methodsIn the Netherlands, ICARES (Integrated Crisis Alert and Response System) has been developed and tested on three syndromes as an automated, real-time tool for early detection of clusters of infectious diseases. From local general practices, General Practice Out-of-Hours services and a hospital, the numbers of routinely used syndrome codes for three piloted tracts i.e., respiratory tract infection, hepatitis and encephalitis/meningitis, are sent on a daily basis to a central unit of infectious disease control. Historic data combined with information about patients' syndromes, age cohort, gender and postal code area have been used to detect clusters of cases.

resultsDuring the first 2 years, two out of eight alerts appeared to be a real cluster. The first was part of the seasonal increase in Enterovirus encephalitis and the second was a remarkably long lasting influenza season with high peak incidence.

conclusionsThis tool is believed to be the first flexible automated, real-time cluster detection system for infectious diseases, based on physician information from both general practitioners and hospitals. ICARES is able to detect and follow small regional clusters in real time and can handle any diseases entity that is regularly registered by first line physicians. Its value will be improved when more health care institutions agree to link up with ICARES thus improving further the signal-to-noise ratio.

Indexed as

Disease OutbreaksElectronic Data ProcessingAdultCluster AnalysisCommunicable Disease ControlCommunicable DiseasesCrew Resource Management, HealthcareFemaleHospitalsHumansIncidenceMaleNetherlandsZika VirusZika Virus InfectionAutomatedCluster detectionHepatitisMeningoencephalitisReal-timeRespiratory tract infection

Identifiers

PMID28279150
PMCPMC5345172
OpenAlexW2593911080

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.