Evidence map›Paper›PMID 28279074›Full record

ArticleAntioxidants & redox signaling2019

Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?

Domenico Tricò, Anna Di Sessa, Sonia Caprio, Naga Chalasani, Wanqing Liu, Tiebing Liang, Joerg Graf, Raimund I Herzog, Casey D Johnson, Giuseppina Rosaria Umano and 2 more

Abstract read
In one paragraph

Article in Antioxidants & redox signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Domenico Tricò1 Department of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut.
Anna Di Sessa2 Department of Pediatrics, Yale University School of Medicine , New Haven, Connecticut.
Sonia Caprio2 Department of Pediatrics, Yale University School of Medicine , New Haven, Connecticut.
Naga Chalasani3 Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Wanqing Liu4 Purdue School of Pharmacy, Purdue University , West Lafayette, Indiana.
Tiebing Liang3 Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Joerg Graf5 Department of Molecular and Cell Biology, University of Connecticut , Hartford, Connecticut.
Raimund I Herzog1 Department of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut.
Casey D Johnson6 Department of Pediatrics, University of California San Diego , San Diego, California.
Giuseppina Rosaria Umano2 Department of Pediatrics, Yale University School of Medicine , New Haven, Connecticut.
Ariel E Feldstein6 Department of Pediatrics, University of California San Diego , San Diego, California.
Nicola Santoro2 Department of Pediatrics, Yale University School of Medicine , New Haven, Connecticut.
Yale University · USUniversity of California, San Diego · USIndiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Richard A Flavell · 1993 to 2026
$44.0M
METABOLIC PREDICTORS AND MARKERS OF CHILDHOOD OBESITYR01HD028016 · NICHD · YALE UNIVERSITY · PI CAPRIO, SONIA · 1991 to 2024
$8.9M
Pathogenesis of youth onset pre-diabetes and Type 2 diabetesR01DK111038 · NIDDK · YALE UNIVERSITY · PI CAPRIO, SONIA · 2016 to 2025
$7.0M
Study to Investigate the Pathophysiology of Type 2 Diabetes in YouthR01HD040787 · NICHD · YALE UNIVERSITY · PI CAPRIO, SONIA · 2000 to 2014
$5.6M
NMR STUDIES OF GLYCOGEN METABOLISM IN HUMANSR01DK049230 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 1995 to 2014
$5.4M
Regulation of Brain Glucose Metabolism in Type 1 DiabetesR01DK101984 · NIDDK · YALE UNIVERSITY · PI HERZOG, RAIMUND INGO · 2014 to 2023
$3.8M
Reversing brain metabolic adaptations to recurrent hypoglycemia in older adults with type 1 diabetes using a Predictive Low Glucose Management (PLGM) systemDP3DK112227 · NIDDK · YALE UNIVERSITY · PI HERZOG, RAIMUND INGO, WEINZIMER, STUART ALAN · 2016 to 2016
$1.9M
NCRR NIH HHS UL1 RR024139NICHD NIH HHS R01 HD028016NICHD NIH HHS R01 HD040787NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK049230NIDDK NIH HHS R01 DK101984NIDDK NIH HHS R01 DK111038
6 · The paper itself

Abstract

We tested whether oxidized linoleic acid metabolites (OXLAM) are associated with pediatric metabolic syndrome (MetS) and a proatherogenic lipoprotein profile in 122 obese adolescents. Furthermore, we examined whether genetic and metagenomic factors can modulate plasma OXLAM concentrations by genotyping the

Indexed as

Disease SusceptibilityOxidation-ReductionAdolescentAge FactorsBiomarkersChildDelta-5 Fatty Acid DesaturaseFatty Acid DesaturasesFemaleGastrointestinal MicrobiomeGenetic BackgroundGenetic Predisposition to DiseaseHaplotypesHumansLinoleic AcidLipid MetabolismBiomarkersDelta-5 Fatty Acid DesaturaseFADS2 protein, humanFatty Acid DesaturasesLinoleic AcidLipoproteinsgenetic predispositiongut microbiotalinoleic acidmetabolic syndromeoxidized low-density lipoproteinsoxidized metabolites of linoleic acidpediatric obesity

Identifiers

PMID28279074
PMCPMC6277079
OpenAlexW2593419578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.