Observational studyRadiology2017
Quantifying Abdominal Adipose Tissue and Thigh Muscle Volume and Hepatic Proton Density Fat Fraction: Repeatability and Accuracy of an MR Imaging-based, Semiautomated Analysis Method.
Registry-linked trialAbstract readObservational Study
In one paragraph
Observational study in Radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05184283 (Longitudinal Assessment of Muscle Health in Patients Undergoing Liver Transplantation), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Longitudinal Assessment of Muscle Health in Patients Undergoing Liver Transplantation (LT) for Hepatocellular Carcinoma (HCC)
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Precision or Paradox? AI-Driven Adiposity Imaging in Women With Overweight and Obesity: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Changes in abdominal adipose tissue depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis.Journal of hepatology · 2023Trial
- Development, validation, and pilot MRI safety study of a high-resolution, open source, whole body pediatric numerical simulation model.PloS one · 2021Trial
- MRI Assessment of Treatment Response in HIV-associated NAFLD: A Randomized Trial of a Stearoyl-Coenzyme-A-Desaturase-1 Inhibitor (ARRIVE Trial).Hepatology (Baltimore, Md.) · 2019Trial
- Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.Alimentary pharmacology & therapeutics · 2018Trial
- Diagnostic accuracy of magnetic resonance imaging hepatic proton density fat fraction in pediatric nonalcoholic fatty liver disease.Hepatology (Baltimore, Md.) · 2018Trial
- Trial
- Adaptive deep learning for quantification and spatial distribution of abdominal adipose tissue from magnetic resonance imaging proton density fat fraction in adults with a body mass index ≥24 kg/mQuantitative imaging in medicine and surgery · 2026Article
- Intra- and inter-rater reliability of skeletal muscle mass MRI assessment among adults: a systematic review.Quantitative imaging in medicine and surgery · 2026Review
- Multiparametric MRI quantitative metrics for grading and staging graves' ophthalmopathy.BMC medical imaging · 2026Article
- Multi-Parametric MRI Approach at 3 T and 7 T for Assessing Skeletal Muscle Pathology in Myofibrillar Myopathies: A Pilot Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Study on Age-Related Facial Fat Changes Using 3D MRI and a Novel Algorithm.Aesthetic surgery journal. Open forum · 2026Article
- Quantifying Leg Muscle Disuse Atrophy During Bed Rest Using DXA, CT, and MRI.European journal of sport science · 2025Article
- BioCompNet: A Deep Learning Workflow Enabling Automated Body Composition Analysis toward Precision Management of Cardiometabolic Disorders.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Quantitative Assessment of Body Composition in Cirrhosis.Diagnostics (Basel, Switzerland) · 2024Review
- Behind BMI: The Potential Indicative Role of Abdominal Ectopic Fat on Glucose Metabolism.Obesity facts · 2024Article
- A rapid, non-invasive, clinical surveillance for CachExia, sarcopenia, portal hypertension, and hepatocellular carcinoma in end-stage liver disease: the ACCESS-ESLD study protocol.BMC gastroenterology · 2023Article
- Repeatability of MRI Biomarkers in Nonalcoholic Fatty Liver Disease: The NIMBLE Consortium.Radiology · 2023Observational
- Review
- Assessment of anterior thigh muscle size and fat infiltration using single-slice CT imaging versus automated MRI analysis in adults.The British journal of radiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Michael S MiddletonFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
William HaufeFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
Jonathan HookerFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
Magnus BorgaFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
Olof Dahlqvist LeinhardFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
Thobias RomuFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
Patrik TunónFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
Gavin HamiltonFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
Tanya WolfsonFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
Anthony GamstFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
Rohit LoombaFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
Claude B SirlinFrom the Liver Imaging Group, Department of Radiology (M.S.M., W.H., J.H., G.H., C.B.S.), Computational and Applied Statistics Laboratory, San Diego Supercomputing Center (T.W., A.G.), and Department of Medicine, Division of Gastroenterology and Hepatology (R.L.), University of California, San Diego, 9500 Gilman Dr, MC 0888, San Diego, CA 92093-0888; Advanced MR Analytics AB, Linköping, Sweden (M.B., O.D.L., T.R., P.T.); and Center for Medical Image Science and Visualization (M.B., O.D.L., T.R.), Department of Biomedical Engineering (M.B., T.R.), and Department of Medicine and Health (O.D.L.), Linköping University, Linköping, Sweden.
San Diego Supercomputer Center · US
Funding
Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1MNIDDK NIH HHS R01 DK088925
Abstract
Purpose To determine the repeatability and accuracy of a commercially available magnetic resonance (MR) imaging-based, semiautomated method to quantify abdominal adipose tissue and thigh muscle volume and hepatic proton density fat fraction (PDFF). Materials and Methods This prospective study was institutional review board- approved and HIPAA compliant. All subjects provided written informed consent. Inclusion criteria were age of 18 years or older and willingness to participate. The exclusion criterion was contraindication to MR imaging. Three-dimensional T1-weighted dual-echo body-coil images were acquired three times. Source images were reconstructed to generate water and calibrated fat images. Abdominal adipose tissue and thigh muscle were segmented, and their volumes were estimated by using a semiautomated method and, as a reference standard, a manual method. Hepatic PDFF was estimated by using a confounder-corrected chemical shift-encoded MR imaging method with hybrid complex-magnitude reconstruction and, as a reference standard, MR spectroscopy. Tissue volume and hepatic PDFF intra- and interexamination repeatability were assessed by using intraclass correlation and coefficient of variation analysis. Tissue volume and hepatic PDFF accuracy were assessed by means of linear regression with the respective reference standards. Results Adipose and thigh muscle tissue volumes of 20 subjects (18 women; age range, 25-76 years; body mass index range, 19.3-43.9 kg/m
Indexed as
Abdominal FatAdiposityAdultDensitometryHumansImage Interpretation, Computer-AssistedLiverMagnetic Resonance SpectroscopyMiddle AgedMuscle, SkeletalNon-alcoholic Fatty Liver DiseaseOrgan SizePattern Recognition, AutomatedProtonsReproducibility of ResultsSensitivity and SpecificityProtons
Identifiers
What OpenQuestion holds
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Registered trials
NCT05184283ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.