Evidence map›Paper›PMID 28277942›Full record

ArticlePrion2017

Hitchhiking vesicular transport routes to the vacuole: Amyloid recruitment to the Insoluble Protein Deposit (IPOD).

Rajesh Kumar, Nicole Neuser, Jens Tyedmers

Open access · goldAbstract read
In one paragraph

Article in Prion, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. International journal of molecular sciences · 2023
    Review
  2. Protein conformation and biomolecular condensates.Current research in structural biology · 2022
    Review
  3. TheeLife · 2020
    Article
  4. The Insoluble Protein Deposit (IPOD) in Yeast.Frontiers in molecular neuroscience · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Rajesh Kumara Department of Medicine I and Clinical Chemistry , University Hospital Heidelberg , Heidelberg , Germany.
Nicole Neusera Department of Medicine I and Clinical Chemistry , University Hospital Heidelberg , Heidelberg , Germany.
Jens Tyedmersa Department of Medicine I and Clinical Chemistry , University Hospital Heidelberg , Heidelberg , Germany.
University Hospital Heidelberg · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sequestration of aggregates into specialized deposition sites occurs in many species across all kingdoms of life ranging from bacteria to mammals and is commonly believed to have a cytoprotective function. Yeast cells possess at least 3 different spatially separated deposition sites, one of which is termed "Insoluble Protein Deposit (IPOD)" and harbors amyloid aggregates. We have recently discovered that recruitment of amyloid aggregates to the IPOD uses an actin cable based recruitment machinery that also involves vesicular transport.

Indexed as

Protein TransportActinsAmyloidAutophagy-Related ProteinsGTP-Binding ProteinsMembrane ProteinsMyosin Heavy ChainsMyosin Type VProtein AggregatesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSolubilityTransport VesiclesVacuolesVesicular Transport ProteinsActinsAmyloidATG9 protein, S cerevisiaeAutophagy-Related ProteinsGTP-Binding ProteinsMembrane ProteinsMYO2 protein, S cerevisiaeMyosin Heavy ChainsMyosin Type VProtein AggregatesSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsVPS1 protein, S cerevisiaeactinamyloid aggregatesAtg9 vesiclesCytoplasm-to-vacuole targeting (CVT) pathwayInsoluble Protein Deposit (IPOD)Myosin motor protein Myo2Phagophore Assembly Site (PAS)prionsSec 14Sec 18vesicular transportVps1yeast (Saccharomyces cerevisiae)

Identifiers

PMID28277942
PMCPMC5399893
OpenAlexW2591919084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.