ArticleJournal of aerosol medicine and pulmonary drug delivery2017
Regional Ventilation Is the Main Determinant of Alveolar Deposition of Coarse Particles in the Supine Healthy Human Lung During Tidal Breathing.
Article in Journal of aerosol medicine and pulmonary drug delivery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Measuring short-term changes in specific ventilation using dynamic specific ventilation imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- The impact of polar fraction of the fine particulate matter on redox responses in different rat tissues.Environmental science and pollution research international · 2019Article
- Regional airflow obstruction after bronchoconstriction and subsequent bronchodilation in subjects without pulmonary disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Pulmonary Delivery of Therapeutic and Diagnostic Gases.Journal of aerosol medicine and pulmonary drug delivery · 2018Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundTo quantify the relationship between regional lung ventilation and coarse aerosol deposition in the supine healthy human lung, we used oxygen-enhanced magnetic resonance imaging and planar gamma scintigraphy in seven subjects.
methodsRegional ventilation was measured in the supine posture in a 15 mm sagittal slice of the right lung. Deposition was measured by using planar gamma scintigraphy (coronal scans, 40 cm FOV) immediately postdeposition, 1 hour 30 minutes and 22 hours after deposition of
resultsr was not significantly different from 1 for all regions (1.04 ± 0.25, 1.08 ± 0.22, 1.03 ± 0.17, 0.92 ± 0.13, apex to diaphragm, p > 0.40) at the alveolar level (r
conclusionsThese results support the hypothesis that alveolar deposition is directly proportional to ventilation for ∼5 μm particles that are inhaled in the supine posture and are consistent with previous simulation predictions that show that convective flow is the main determinant of aerosol transport to the lung periphery.
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