ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2017
Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential.
Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed.
- Genetic Diversity of Clade 2.3.4.4b H5Nx high pathogenicity Avian Influenza Viruses detected in Korea during the 2025-2026 winter season and pathogenicity of H5N1 and H5N9 viruses.Virus research · 2026Article
- Molecular Evolution of the H5 and H7 Highly Pathogenic Avian Influenza Virus Haemagglutinin Cleavage Site Motif.Reviews in medical virology · 2025Review
- Phylogenetic Insights into H7Nx Influenza Viruses: Uncovering Reassortment Patterns and Geographic Variability.Viruses · 2024Article
- Genetic Diversity of Avian Influenza Viruses Detected in Waterbirds in Northeast Italy Using Two Different Sampling Strategies.Animals : an open access journal from MDPI · 2024Article
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- SARS-CoV-2 genomics and impact on clinical care for COVID-19.The Journal of antimicrobial chemotherapy · 2023Article
- Whole genome sequencing and phylogenetic characterisation of rabies virus strains from Moldova and north-eastern Romania.PLoS neglected tropical diseases · 2023Article
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- Investigations on SARS-CoV-2 and other coronaviruses in mink farms in France at the end of the first year of COVID-19 pandemic.bioRxiv : the preprint server for biology · 2023Article
- Investigations into SARS-CoV-2 and other coronaviruses on mink farms in France late in the first year of the COVID-19 pandemic.PloS one · 2023Article
- Hemagglutinin Subtype Specificity and Mechanisms of Highly Pathogenic Avian Influenza Virus Genesis.Viruses · 2022Review
- A new clade 2.3.4.4b H5N1 highly pathogenic avian influenza genotype detected in Europe in 2021.Archives of virology · 2022Article
- Pathobiology of highly pathogenic H5 avian influenza viruses in naturally infected Galliformes and Anseriformes in France during winter 2015-2016.Veterinary research · 2022Article
- High-throughput sequencing technologies in the detection of livestock pathogens, diagnosis, and zoonotic surveillance.Computational and structural biotechnology journal · 2022Review
- Article
- Pathobiological Origins and Evolutionary History of Highly Pathogenic Avian Influenza Viruses.Cold Spring Harbor perspectives in medicine · 2021Review
- Highly Pathogenic Avian Influenza A(H5N8) Virus Spread by Short- and Long-Range Transmission, France, 2016-17.Emerging infectious diseases · 2021Article
- Natural and Experimental Persistence of Highly Pathogenic H5 Influenza Viruses in Slurry of Domestic Ducks, with or without Lime Treatment.Applied and environmental microbiology · 2020Article
- The Microbiota Contributes to the Control of Highly Pathogenic H5N9 Influenza Virus Replication in Ducks.Journal of virology · 2020Article
- Role of Live-Duck Movement Networks in Transmission of Avian Influenza, France, 2016-2017.Emerging infectious diseases · 2020Article
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23 authors.
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Abstract
Several new highly pathogenic (HP) H5 avian influenza virus (AIV) have been detected in poultry farms from south-western France since November 2015, among which an HP H5N1. The zoonotic potential and origin of these AIVs immediately became matters of concern. One virus of each subtype H5N1 (150169a), H5N2 (150233) and H5N9 (150236) was characterised. All proved highly pathogenic for poultry as demonstrated molecularly by the presence of a polybasic cleavage site in their HA protein - with a sequence (HQRRKR/GLF) previously unknown among avian H5 HPAI viruses - or experimentally by the in vivo demonstration of an intravenous pathogenicity index of 2.9 for the H5N1 HP isolate. Phylogenetic analyses based on the full genomes obtained by NGS confirmed that the eight viral segments of the three isolates were all part of avian Eurasian phylogenetic lineage but differed from the Gs/Gd/1/96-like lineage. The study of the genetic characteristics at specific amino acid positions relevant for modulating the adaptation to and the virulence for mammals showed that presently, these viruses possess most molecular features characteristic of AIV and lack some major characteristics required for efficient respiratory transmission to or between humans. The three isolates are therefore predicted to have no significant pandemic potential.
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