Evidence map›Paper›PMID 28277161›Full record

ArticleBioengineered2017

Regulation function of MMP-1 downregulated by siRNA on migration of heat-denatured dermal fibroblasts.

Xianghui He, Jinhua Dai, Youfen Fan, Chun Zhang, Xihong Zhao

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. A WR3-NHMaterials today. Bio · 2026
    Article
  2. Article
  3. Expression of a New Recombinant Collagenase Protein ofIranian journal of biotechnology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xianghui Hea Department of Burn , Ningbo No. 2 Hospital, Ningbo , China.
Jinhua Daib Department of Clinical Laboratory , Ningbo No. 2 Hospital, Ningbo , China.
Youfen Fana Department of Burn , Ningbo No. 2 Hospital, Ningbo , China.
Chun Zhanga Department of Burn , Ningbo No. 2 Hospital, Ningbo , China.
Xihong Zhaoc Key Laboratory for Green Chemical Process of Ministry of Education , School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology , Wuhan , China.
Ningbo No. 2 Hospital · CNWuhan Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous wound healing is a complex physiological process that requires the efforts of various cell types and signaling pathways and often results in thickened collagen-enriched healed tissue called a scar. Therefore, the identification of the mechanism of cutaneous wound healing is necessary and has great value in providing better treatment. Here, we demonstrated that MMP-1 inhibition could promote cell proliferation in dermal fibroblasts via the MTT assay. Meanwhile, we investigated cell migration by flow cytometry and tested type I collagenase activity. We found that MMP-1 inhibition promoted cell proliferation and inhibited cell migration and type I collagenase activity. In conclusion, our study demonstrated that MMP-1 might be a potential therapeutic target in cutaneous wound healing.

Indexed as

Blotting, WesternCell MovementCollagenasesFibroblastsHumansMatrix Metalloproteinase 1Reverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingSkinCollagenasesMatrix Metalloproteinase 1MMP1 protein, humanRNA, Small Interferingheat-denatured dermal fibroblastmigrationMMP-1siRNATIMP

Identifiers

PMID28277161
PMCPMC5736340
OpenAlexW2591248065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.