Evidence map›Paper›PMID 28276640›Full record

ReviewOrthopaedic surgery2017

Prospective Review of Mesenchymal Stem Cells Differentiation into Osteoblasts.

Priyanka Garg, Matthew M Mazur, Amy C Buck, Meghan E Wandtke, Jiayong Liu, Nabil A Ebraheim

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Orthopaedic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 2 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 2 syntheses or guidelines pooled it, 194 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Priyanka GargDepartment of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, Ohio, USA.
Matthew M MazurDepartment of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, Ohio, USA.
Amy C BuckDepartment of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, Ohio, USA.
Meghan E WandtkeDepartment of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, Ohio, USA.
Jiayong LiuDepartment of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, Ohio, USA.
Nabil A EbraheimDepartment of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, Ohio, USA.
University of Toledo Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell research has been a popular topic in the past few decades. This review aims to discuss factors that help regulate, induce, and enhance mesenchymal stem cell (MSC) differentiation into osteoblasts for bone regeneration. The factors analyzed include bone morphogenic protein (BMP), transforming growth factor β (TGF-β), stromal cell-derived factor 1 (SDF-1), insulin-like growth factor type 1 (IGF-1), histone demethylase JMJD3, cyclin dependent kinase 1 (CDK1), fucoidan, Runx2 transcription factor, and TAZ transcriptional coactivator. Methods promoting bone healing are also evaluated in this review that have shown promise in previous studies. Methods tested using animal models include low intensity pulsed ultrasound (LIPUS) with MSC, micro motion, AMD3100 injections, BMP delivery, MSC transplantation, tissue engineering utilizing scaffolds, anti-IL-20 monoclonal antibody, low dose photodynamic therapy, and bone marrow stromal cell transplants. Human clinical trial methods analyzed include osteoblast injections, bone marrow grafts, bone marrow and platelet rich plasma transplantation, tissue engineering using scaffolds, and recombinant human BMP-2. These methods have been shown to promote and accelerate new bone formation. These various methods for enhanced bone regeneration have the potential to be used, following further research, in clinical practice.

Indexed as

AnimalsBone Marrow TransplantationBone RegenerationCell DifferentiationCell MovementFracture HealingFractures, BoneHumansMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOsteoblastsUltrasonic TherapyAnimal trialsBone regenerationClinical trialsMesenchymal stem cellsOsteoblastsRelated factors

Identifiers

PMID28276640
PMCPMC6584428
OpenAlexW2593848038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.