SynthesisJournal of evidence-based medicine2018
Community-deliverable exercise and depression in adults with arthritis: Confirmatory evidence of a meta-analysis using the IVhet model.
Synthesis in Journal of evidence-based medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Objective medication adherence and persistence in people with multiple sclerosis: a systematic review, meta-analysis, and meta-regression.Journal of managed care & specialty pharmacy · 2021Pooled it
- Topical Diclofenac Solution for Osteoarthritis of the Knee: An Updated Meta-Analysis of Randomized Controlled Trials.BioMed research international · 2020Pooled it
- Mental Health and Psychological Wellbeing in Rheumatoid Arthritis during COVID-19 - Can Physical Activity Help?Mediterranean journal of rheumatology · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveUsing the traditional random-effects model, a recently reported standardized effect size (g) reduction of -0.42 (95% CI, -0.58 to -0.27) was observed in depressive symptoms as a result of community-deliverable exercise in adults with arthritis and other rheumatic diseases. However, a recently proposed alternative model (IVhet) has been shown to have superior coverage probability to the random-effects model. The purpose of this brief report was to compare these previous random-effects results with the IVhet model.
methodsBased on a previous meta-analysis of 35 g's representing 2449 participants, results for depressive symptoms were pooled using the IVhet model. Influence analysis, number needed-to-treat, percentile improvement, and gross estimates of the number of inactive adults with arthritis who could benefit from exercise were also calculated.
resultsThe IVhet model yielded statistically significant reductions in depressive symptoms (g = -0.30, 95% CI, -0.49 to -0.11), a difference that was -0.12 (28.7%) smaller than the random-effects model. With each study deleted from the model once, results remained statistically significant, ranging from -0.28 to -0.34. The percentile improvement, number needed-to-treat, and estimated number of people with arthritis in the United States who could improve their depressive symptoms by participating in a regular exercise program were, respectively, 11.8% (95% CI, 4.5% to 18.8%), 8 (95% CI, 5 to 23), and 2.7 million (95% CI, 1.0 to 4.4 million).
conclusionsThese findings provide more conservative and accurate evidence that community-deliverable exercise improves depressive symptoms in adults with arthritis and other rheumatic diseases. Future meta-analyses may want to consider using the IVhet versus traditional random-effects model.
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