Evidence map›Paper›PMID 28276488›Full record

ArticleScientific reports2017

TASK channels contribute to neuroprotective action of inhalational anesthetics.

Chengye Yao, Yu Li, Shaofang Shu, Shanglong Yao, Carl Lynch, Douglas A Bayliss, Xiangdong Chen

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Dynamic regulation of TASK-1 channels under cellular stress.The journal of physiological sciences : JPS · 2026
    Article
  2. Neuroprotective Strategies in Coronary Artery Disease Interventions.Journal of cardiovascular development and disease · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. TASK-3: New Target for Pain-Relief.Neuroscience bulletin · 2020
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Chengye YaoDepartment of Anesthesiology, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.
Yu LiDepartment of Anesthesiology, Linyi People's Hospital, Shandong, 276000 China.
Shaofang ShuDepartment of Anesthesiology, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.
Shanglong YaoDepartment of Anesthesiology, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.
Carl LynchDepartments of Anesthesiology, University of Virginia, Charlottesville, 22901 Virginia, USA.
Douglas A BaylissDepartments of Pharmacology and Anesthesiology, University of Virginia, Charlottesville, 22901 Virginia, USA.
Xiangdong ChenDepartment of Anesthesiology, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.
Huazhong University of Science and Technology · CNUnion Hospital · CNUniversity of Virginia · USLinyi People's Hospital · CN

Funding

Anesthetic Action: Molecular Substrates & Neural MechanismsR01GM066181 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BAYLISS, DOUGLAS A. · 2002 to 2013
$3.7M
NIGMS NIH HHS R01 GM066181
6 · The paper itself

Abstract

Postconditioning with inhalational anesthetics can reduce ischemia-reperfusion brain injury, although the cellular mechanisms for this effect have not been determined. The current study was designed to test if TASK channels contribute to their neuroprotective actions. Whole cell recordings were used to examine effects of volatile anesthetic on TASK currents in cortical neurons and to verify loss of anesthetic-activated TASK currents from TASK

Indexed as

Anesthetics, InhalationAnimalsBrain IschemiaCerebral CortexIsofluraneMethyl EthersMiceMice, KnockoutNerve Tissue ProteinsNeuroprotective AgentsPotassium Channels, Tandem Pore DomainReperfusion InjurySevofluraneAnesthetics, InhalationIsofluraneMethyl EthersNerve Tissue ProteinsNeuroprotective AgentsPotassium Channels, Tandem Pore Domainpotassium channel subfamily K member 3Sevoflurane

Identifiers

PMID28276488
PMCPMC5343576
OpenAlexW2592804238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.