ArticleScientific reports2017
miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The role of HMGB1 in vascular endothelial cells.Apoptosis : an international journal on programmed cell death · 2026Review
- Article
- Article
- Integrative Bioinformatics Analysis Reveals a Transcription Factor EB-Driven MicroRNA Regulatory Network in Endothelial Cells.International journal of molecular sciences · 2024Article
- Recent advances in endothelial colony-forming cells: from the transcriptomic perspective.Journal of translational medicine · 2024Review
- Enhancing endothelial colony-forming cells for treating diabetic vascular complications: challenges and clinical prospects.Frontiers in endocrinology · 2024Review
- Developmental expression of high-mobility group box 1 (HMGB1) in the mouse cochlea.European journal of histochemistry : EJH · 2023Article
- Unraveling Therapeutic Opportunities and the Diagnostic Potential of microRNAs for Human Lung Cancer.Pharmaceutics · 2023Review
- Comparison of porcine milk microRNA expression in milk exosomes versus whole swine milk and prediction of target genes.Archives animal breeding · 2022Article
- LINC00460 Stimulates the Proliferation of Vascular Endothelial Cells by Downregulating miRNA-24-3p.Disease markers · 2022Article
- The TBX1/miR-193a-3p/TGF-Oxidative medicine and cellular longevity · 2022Article
- Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas.Bioscience reports · 2021Article
- MicroRNA Profiles of Maternal and Neonatal Endothelial Progenitor Cells in Preeclampsia.International journal of molecular sciences · 2021Article
- microRNA Sequencing of CD34+ Sorted Adipose Stem Cells Undergoing Endotheliogenesis.Stem cells and development · 2021Article
- Diagnostic value of miR-92a in asymptomatic carotid artery stenosis patients and its ability to predict cerebrovascular events.Diagnostic pathology · 2020Article
- miR-193a-3p Mediates Placenta Accreta Spectrum Development by Targeting EFNB2 via Epithelial-Mesenchymal Transition Pathway Under Decidua Defect Conditions.Frontiers in molecular biosciences · 2020Article
- High-Mobility Group Box 1 (HMGB1) Induces Migration of Endothelial Progenitor Cell via Receptor for Advanced Glycation End-Products (RAGE)-Dependent PI3K/Akt/eNOS Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Article
- Limited differential expression of miRNAs and other small RNAs in LPS-stimulated human monocytes.PloS one · 2019Article
- The Expression Profile of MicroRNAs in Small and Large Abdominal Aortic Aneurysms.Cardiology research and practice · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
Circulating endothelial colony forming cells (ECFCs) contribute to vascular repair where they are a target for therapy. Since ECFC proliferative potential is increased in cord versus peripheral blood and to define regulatory factors controlling this proliferation, we compared the miRNA profiles of cord blood and peripheral blood ECFC-derived cells. Of the top 25 differentially regulated miRNAs selected, 22 were more highly expressed in peripheral blood ECFC-derived cells. After validating candidate miRNAs by q-RT-PCR, we selected miR-193a-3p for further investigation. The miR-193a-3p mimic reduced cord blood ECFC-derived cell proliferation, migration and vascular tubule formation, while the miR-193a-3p inhibitor significantly enhanced these parameters in peripheral blood ECFC-derived cells. Using in silico miRNA target database analyses combined with proteome arrays and luciferase reporter assays of miR-193a-3p mimic treated cord blood ECFC-derived cells, we identified 2 novel miR-193a-3p targets, the high mobility group box-1 (HMGB1) and the hypoxia upregulated-1 (HYOU1) gene products. HMGB1 silencing in cord blood ECFC-derived cells confirmed its role in regulating vascular function. Thus, we show, for the first time, that miR-193a-3p negatively regulates human ECFC vasculo/angiogenesis and propose that antagonising miR-193a-3p in less proliferative and less angiogenic ECFC-derived cells will enhance their vasculo/angiogenic function.
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