SynthesisExpert review of vaccines2017
Severe varicella in persons vaccinated with varicella vaccine (breakthrough varicella): a systematic literature review.
Synthesis in Expert review of vaccines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 71 citations in OpenAlex.
- Immunogenicity and safety of a live attenuated varicella vaccine co-administered with inactive hepatitis A vaccine: A phase 4, single-center, randomized, controlled trial.Human vaccines & immunotherapeutics · 2023Trial
- A Cross-Sectional Seroepidemiological Study on Varicella Zoster Virus in Zhejiang, China.Vaccines · 2026Article
- Varicella zoster virus and the central nervous system.Nature reviews. Microbiology · 2026Review
- Seroconversion following varicella vaccination in children and adolescents with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Article
- Breakthrough Varicella During Chemotherapy in Two Vaccinated Children With Acute Leukemia.Cureus · 2026Article
- Investigation and analysis of influencing factors on the economic burden of varicella disease in Qingyang, China, 2024.Human vaccines & immunotherapeutics · 2025Article
- Effectiveness of Universal Varicella Vaccination after ten years of implementation in Tuscany (Central Italy).Human vaccines & immunotherapeutics · 2025Article
- Article
- Changes in Epidemiological Characteristics of Varicella and Breakthrough Cases in Ningbo, China, From 2010 to 2023: Surveillance Study.JMIR public health and surveillance · 2025Article
- Article
- Surveillance of Adverse Events Following Varicella Vaccine Immunization in Zhejiang Province, China, from 2020 to 2022.Vaccines · 2025Article
- Varicella vaccine effectiveness evaluation in Wuxi, China: A retrospective cohort study.Epidemiology and infection · 2024Article
- Surveillance of adverse events following varicella vaccine immunization in Jiangsu province, China from 2017 to 2023.BMC infectious diseases · 2024Article
- Clinical and radiological features of a cluster of immunocompetent adolescents with varicella pneumonia: a descriptive study.Journal of thoracic disease · 2024Article
- Advances in Alpha Herpes Viruses Vaccines for Human.Vaccines · 2023Review
- Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria: An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2023Article
- Evaluating the impact of universal varicella vaccination among preschool-aged children in Qingdao, China: An interrupted time-series analysis.Human vaccines & immunotherapeutics · 2022Article
- Clinical Manifestations of Varicella: Disease Is Largely Forgotten, but It's Not Gone.The Journal of infectious diseases · 2022Article
- Epidemiological analysis of varicella in Dalian from 2009 to 2019 and application of three kinds of model in prediction prevalence of varicella.BMC public health · 2022Article
- From Genetics to Epigenetics: Top 4 Aspects for Improved SARS-CoV-2 Vaccine Designs as Paradigmatic Examples.Global medical genetics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
introductionVaricella vaccines are highly effective at preventing disease, but varicella may occur among vaccinated persons (termed breakthrough varicella). Breakthrough varicella is generally mild, but severe cases have been reported. The objective of this review is to describe severe breakthrough varicella. Areas covered: We conducted a systematic review of articles published during 1974-2016. A total of 34 articles were included in our review: 21 described breakthrough varicella with disseminated varicella-zoster virus (VZV) infection with other organ involvement in addition to skin (none among two-dose vaccinees); 9 described hospitalized breakthrough varicella without mention of other organ involvement in addition to skin (of which 2 reported 4 two-dose vaccinees); and 4 described both. A total of 52-60 unique breakthrough varicella cases with disseminated VZV infection with other organ involvement in addition to skin reported with the following complications, not mutually exclusive: pneumonia (n = 8-9 cases), neurologic (n = 18-24 cases), hematologic (n = 10-11 cases), ocular (n = 5 cases), renal (n = 2 cases), hepatic (n = 3 cases), secondary infection with bacteremia or sepsis (n = 8 cases), and other complication (n = 4 cases). There were 6 cases of fatal breakthrough varicella. Expert commentary: With >31 million doses distributed annually worldwide since 2007, severe breakthrough varicella can occur but they appear to be uncommon.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.