Evidence map›Paper›PMID 28276007›Full record

ArticleJournal of endocrinological investigation2017

Investigation on the association between thyroid tumorigeneses and herpesviruses.

J F M Almeida, A H Campos, M A Marcello, N E Bufalo, C L Rossi, L H P Amaral, A B Marques, L L Cunha, C A Alvarenga, P C Tincani and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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  12. Epstein-Barr virus and thyroid cancer: the controversy remains.Journal of endocrinological investigation · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

J F M AlmeidaLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Tessália Vieira de Camargo Street, 126, Cidade Universitária, Campinas, São Paulo, 13083-887, Brazil.
A H CamposDepartment of Anatomic Pathology, AC Camargo Cancer Center, Taguá Street, 440, Liberdade, São Paulo, SP, 01508-010, Brazil.
M A MarcelloLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Tessália Vieira de Camargo Street, 126, Cidade Universitária, Campinas, São Paulo, 13083-887, Brazil.
N E BufaloLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Tessália Vieira de Camargo Street, 126, Cidade Universitária, Campinas, São Paulo, 13083-887, Brazil.
C L RossiClinical Pathology Department, Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Vital Brasil Street, 251, Cidade Universitária, Campinas, São Paulo, 13083-888, Brazil.
L H P AmaralLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Tessália Vieira de Camargo Street, 126, Cidade Universitária, Campinas, São Paulo, 13083-887, Brazil.
A B MarquesLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Tessália Vieira de Camargo Street, 126, Cidade Universitária, Campinas, São Paulo, 13083-887, Brazil.
L L CunhaLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Tessália Vieira de Camargo Street, 126, Cidade Universitária, Campinas, São Paulo, 13083-887, Brazil.
C A AlvarengaLaboratory of Pathology, Clinical Pathology Institute (IPC), Av. Orosimbo Maia, 165, Vila Itapura, Campinas, São Paulo, 13023-002, Brazil.
P C TincaniLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Tessália Vieira de Camargo Street, 126, Cidade Universitária, Campinas, São Paulo, 13083-887, Brazil.
A J TincaniHead and Neck Surgery Department, University of Campinas Teaching Hospital (HC-Unicamp), Vital Brasil Street, 251, Cidade Universitária, Campinas, SP, 13083-888, Brazil.
L S WardLaboratory of Cancer Molecular Genetics (Gemoca), Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Tessália Vieira de Camargo Street, 126, Cidade Universitária, Campinas, São Paulo, 13083-887, Brazil. ward@fcm.unicamp.br.
Universidade Estadual de Campinas (UNICAMP) · BRAC Camargo Hospital · BRHospital de Clínicas da Unicamp · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpesviruses have been associated with various human malignancies and with thyroid autoimmunity. Aiming to investigate the presence of these viruses in thyroid nodules, we analyzed serum and thyroid tissue from 183 patients (83 benign and 100 malignant thyroid nodules). We also obtained 104 normal thyroid tissues extracted from the contralateral lobe of these patients. We used ELISA to screen the serology of all patients and a real-time quantitative PCR to analyze thyroid tissue viral load in antibody-positive patients. In addition, the presence of herpesviruses was tested by histological analysis in 20 EBV-positive tissues using the expression of LMP-1 by immunohistochemistry (IHC) and EBER by in situ hybridization (ISH). There was no evidence of HSV-2 or CMV DNA, but we found EBV DNA sequences in 29 (16%) thyroid tissue samples. We also found 7 positive EBV cases out of 104 normal tissues. Viral load was higher in tumors than in their respective normal tissues (p = 0.0002). ISH analysis revealed EBER expression in 11 out of 20 (52%) EBV-positive tissues, mostly in malignant cases (8/11, 73%). The presence of high EBV copy numbers in thyroid tumors and the expression of EBER only in malignant cases suggest an association between EBV and thyroid malignancies. However, we did not find any association between the presence of EBV and/or its viral load and any clinical or pathological tumor feature. Further studies aiming to clarify the mechanisms of EBV infection in thyroid cells are necessary to support a possible role in the development of thyroid cancer.

Indexed as

BrazilCase-Control StudiesDNA, ViralEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansMaleMiddle AgedPrevalenceThyroid GlandThyroid NeoplasmsDNA, ViralEpstein–Barr virus infectionHerpesvirusThyroid cancer.Thyroid nodulesViral load

Identifiers

PMID28276007
OpenAlexW2594529033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.