Evidence map›Paper›PMID 28275892›Full record

SynthesisThe Psychiatric quarterly2017

Rapid Tranquilization for Psychiatric Patients with Psychomotor Agitation: What is Known About it?

Clayton Gonçalves de Almeida, Mariana Del Grossi Moura, Silvio Barberato-Filho, Fernando de Sá Del Fiol, Rogério Heládio Lopes Motta, Cristiane de Cássia Bergamaschi

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in The Psychiatric quarterly, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Clayton Gonçalves de AlmeidaPharmaceutical Sciences, University of Sorocaba, Rodovia Raposo Tavares, Km 92,5, Sorocaba, State of São Paulo, 18023-000, Brazil.
Mariana Del Grossi MouraPharmaceutical Sciences, University of Sorocaba, Rodovia Raposo Tavares, Km 92,5, Sorocaba, State of São Paulo, 18023-000, Brazil.
Silvio Barberato-FilhoPharmaceutical Sciences, University of Sorocaba, Rodovia Raposo Tavares, Km 92,5, Sorocaba, State of São Paulo, 18023-000, Brazil.
Fernando de Sá Del FiolPharmaceutical Sciences, University of Sorocaba, Rodovia Raposo Tavares, Km 92,5, Sorocaba, State of São Paulo, 18023-000, Brazil.
Rogério Heládio Lopes MottaDepartment of Pharmacology, Anesthesiology and Therapeutics Dental School and Research Center, Sorocaba, Brazil.
Cristiane de Cássia BergamaschiPharmaceutical Sciences, University of Sorocaba, Rodovia Raposo Tavares, Km 92,5, Sorocaba, State of São Paulo, 18023-000, Brazil. cristiane.motta@prof.uniso.br.
Universidade de Sorocaba · BR

Funding

none none
6 · The paper itself

Abstract

Rapid tranquilization is an intervention used in control of agitation or aggression in patients with mental disorders. This study synthesized the available evidence regarding efficacy and safety of drugs used for rapid tranquilization in psychiatric patients with psychomotor agitation. It is an overview study of systematic reviews and meta-analysis of randomized controlled trials (RCT) identified in the database MEDLINE, EMBASE, CINAHL, Web of Science, Cochrane Library and LILACS until April 2015. A team of reviewers, in pairs and independently, identified eligible studies and assessed methodological quality using AMSTAR. Data were extracted from four studies (61 RCT, 8021 participants). The association of haloperidol with promethazine (H + P) promoted tranquilization and presented better safety profile, with moderate quality evidence. Olanzapine demonstrated benefit towards tranquilization and good safety profile, but needed additional administration to keep tranquilization. There was no benefit in the use of haloperidol alone or associated to another psychotropic to most outcomes evaluated. The evidence was of low quality to most of the interventions. H + P was considered a good option for rapid tranquilization, however, more RCT are necessary to confirm the efficacy and safety of the available interventions.

Indexed as

HumansMental DisordersPsychomotor AgitationTranquilizing AgentsTranquilizing AgentsMental disordersPsychomotor agitationTranquilizing agents

Identifiers

PMID28275892
OpenAlexW2592634462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.