ArticlePediatric nephrology (Berlin, Germany)2017
Longitudinal assessment of myocardial function in childhood chronic kidney disease, during dialysis, and following kidney transplantation.
Article in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Cardiac adaptation in pediatric kidney transplant recipients with large donor-recipient size discrepancy: a speckle-tracking echocardiography study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Diastolic echocardiographic parameters identify pediatric kidney transplant recipients with structural myocardial alterations.Pediatric nephrology (Berlin, Germany) · 2026Article
- Left ventricular remodeling by cardiac magnetic resonance in children with advanced chronic kidney disease: an analysis of the Chronic Kidney Disease in Children (CKiD) study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Left heart function and strain for predicting change in hemoglobin levels in pediatric kidney transplantation recipients.Frontiers in pediatrics · 2025Article
- Hypertension and Left Ventricular Strain in Pediatric Chronic Kidney Disease.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Changes in Cardiac Structure and Function of Recipients after Kidney Transplantation.Journal of clinical medicine · 2024Article
- Physical activity and its impact on cardiovascular health in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2024Article
- Evaluation of the effect of kidney transplantation on left ventricular myocardial work by noninvasive pressure-strain loops.Frontiers in cardiovascular medicine · 2024Article
- Alterations in diastolic function and cardiac geometry in children: a longitudinal study across the spectrum of dialysis and transplant.Pediatric nephrology (Berlin, Germany) · 2023Article
- Hypertension in Pediatric Solid Organ Transplant Recipients.Current hypertension reports · 2023Review
- Echocardiogram screening in pediatric dialysis and transplantation.Pediatric nephrology (Berlin, Germany) · 2023Review
- Get to the heart of pediatric kidney transplant recipients: Evaluation of left- and right ventricular mechanics by three-dimensional echocardiography.Frontiers in cardiovascular medicine · 2023Article
- Changes in myocardial work associated with pediatric kidney transplantation: A pilot study of short-term postoperative effect.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Subclinical cardiac dysfunction in pediatric kidney transplant recipients identified by speckle-tracking echocardiography.Pediatric nephrology (Berlin, Germany) · 2022Article
- Left ventricular strain and left atrial strain are impaired during hemodialysis in children.The international journal of cardiovascular imaging · 2021Article
- Perioperative anesthesia care for the pediatric patient undergoing a kidney transplantation: An educational review.Paediatric anaesthesia · 2021Review
- Reducing the burden of cardiovascular disease in children with chronic kidney disease: prevention vs. damage limitation.Pediatric nephrology (Berlin, Germany) · 2021Review
- Left Ventricular Myocardial Deformations in Hemodialysis Children by Speckle Tracking Echocardiography.Clinical Medicine Insights. Cardiology · 2020Article
- Cardiovascular risk factors in children on dialysis: an update.Pediatric nephrology (Berlin, Germany) · 2020Review
- Beyond playing games: nephrologist vs machine in pediatric dialysis prescribing.Pediatric nephrology (Berlin, Germany) · 2018Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildhood chronic kidney disease (CKD) and dialysis are associated with increased long-term cardiovascular risk. We examined subclinical alterations in myocardial mechanics longitudinally in children with CKD, during dialysis, and following renal transplantation.
methodsForty-eight children with CKD (stage III or higher) who received kidney transplants from 2008 to 2014 were included in a retrospective study and compared to 192 age- and sex-matched healthy children. Measurements of cardiac systolic and diastolic function were performed, and global longitudinal strain (GLS) and circumferential strain (GCS) were measured by speckle-tracking echocardiography at CKD, during dialysis, and 1 year following kidney transplantation. Mixed-effects modeling examined changes in GLS and GCS over different disease stages.
resultsChildren with CKD had a mean age of 10 ± 5 years and 67% were male. Eighteen children received preemptive transplantation. Children with CKD had increased left ventricular mass, lower GLS, and impaired diastolic function (lower E/A ratio and E' velocities) than healthy children. Changes in left ventricular diastolic parameters persisted during dialysis and after renal transplantation. Dialysis was associated with reduced GLS compared to CKD (β = 1.6, 95% confidence interval 0.2-3.0); however, this was not significant after adjustment for systolic blood pressure and CKD duration. Post-transplantation GLS levels were similar to those at CKD assessment. GCS was unchanged during dialysis but significantly improved following transplantation.
conclusionsThere are differences in diastolic parameters in childhood CKD that persist during dialysis and after transplantation. Systolic parameters are preserved, with significant improvement in systolic myocardial deformation following transplantation. The impact of persistent diastolic changes on long-term outcomes requires further investigation.
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