Evidence map›Paper›PMID 28275718›Full record

ArticleeNeuro

Context-Dependent Modulation of Excitatory Synaptic Strength by Synaptically Released Zinc.

Bopanna I Kalappa, Thanos Tzounopoulos

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. ZIP-ZnT1 complexes mediate a local ZnCellular and molecular life sciences : CMLS · 2026
    Article
  4. Review
  5. Synaptic Properties of Layer 6 Auditory Corticothalamic Inputs in Normal Hearing and Noise-Induced Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Cell-type-specific enhancement of deviance detection by synaptic zinc in the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Neuromodulatory Mechanisms Underlying Contrast Gain Control in Mouse Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  14. Review
  15. Article
  16. Mechanisms Underlying Long-Term Synaptic Zinc Plasticity at Mouse Dorsal Cochlear Nucleus Glutamatergic Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  17. Article
  18. Article
  19. Intracellular ZnScientific reports · 2019
    Article
  20. Fine Control of Sound Frequency Tuning and Frequency Discrimination Acuity by Synaptic Zinc Signaling in Mouse Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bopanna I KalappaDepartments of Otolaryngology and Neurobiology, University of Pittsburgh , Pittsburgh, PA 15261.
Thanos TzounopoulosDepartments of Otolaryngology and Neurobiology, University of Pittsburgh , Pittsburgh, PA 15261.ORCID 0000-0003-4583-145X
University of Pittsburgh · US

Funding

Cell-specific Synaptic Plasticity in the Auditory BrainstemR01DC007905 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TZOUNOPOULOS, THANOS · 2007 to 2021
$6.9M
NIDCD NIH HHS R01 DC007905
6 · The paper itself

Abstract

Synaptically released zinc inhibits baseline excitatory neurotransmission; however, the role of this neuromodulator on short-term plasticity during different levels of synaptic activity remains largely unknown. This lack of knowledge prevents our understanding of information transfer across zinc-releasing synapses, including 50% of excitatory synapses in cortical areas. We used

Indexed as

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAuditory PathwaysBrain StemEndocannabinoidsExcitatory Postsynaptic PotentialsFemaleMice, Inbred ICRNeural InhibitionNeuronal PlasticityNeurotransmitter AgentsSynapsesSynaptic VesiclesTissue Culture TechniquesZincalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidEndocannabinoidsNeurotransmitter AgentsZincauditory brainstemauditory synapsesshort-term plasticitysynaptic zincZnT3

Identifiers

PMID28275718
PMCPMC5334633
OpenAlexW2588376364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.