Evidence map›Paper›PMID 28275709›Full record

ArticleeNeuro

Caudal Nucleus Accumbens Core Is Critical in the Regulation of Cue-Elicited Approach-Avoidance Decisions.

Laurie Hamel, Tharshika Thangarasa, Osai Samadi, Rutsuko Ito

Abstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. How Distributed Subcortical Integration of Reward and Threat May Inform Subsequent Approach-Avoidance Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  7. Article
  8. Ventral Pallidum and Amygdala Cooperate to Restrain Reward Approach under Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Cortico-Striatal Control over Adaptive Goal-Directed Responding Elicited by Cues Signaling Sucrose Reward or Punishment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Insular Cortex Projections to Nucleus Accumbens Core Mediate Social Approach to Stressed Juvenile Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  19. An insular view of the social decision-making network.Neuroscience and biobehavioral reviews · 2019
    Review
  20. α5GABAPsychopharmacology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laurie HamelDepartment of Psychology (Scarborough), University of Toronto , 1265 Military Trail , Toronto, Ontario M1C 1A4, Canada.
Tharshika ThangarasaDepartment of Psychology (Scarborough), University of Toronto , 1265 Military Trail , Toronto, Ontario M1C 1A4, Canada.
Osai SamadiDepartment of Psychology (Scarborough), University of Toronto , 1265 Military Trail , Toronto, Ontario M1C 1A4, Canada.
Rutsuko ItoDepartment of Psychology (Scarborough), University of Toronto, 1265 Military Trail, Toronto, Ontario M1C 1A4, Canada; Department of Cell and Systems Biology, Ramsay Wright Laboratories, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada.ORCID 0000-0003-1769-5470

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nucleus accumbens (NAc) is thought to be a site of integration of positively and negatively valenced information and action selection. Functional differentiation in valence processing has previously been found along the rostrocaudal axis of the shell region of the NAc in assessments of unconditioned motivation. Given that the core region of the NAc has been implicated in the elicitation of motivated behavior in response to conditioned cues, we sought to assess the role of caudal, intermediate, and rostral sites within this subregion in cue-elicited approach-avoidance decisions. Rats were trained to associate visuo-tactile cues with appetitive, aversive, and neutral outcomes. Following the successful acquisition of the cue-outcome associations, rats received microinfusions of GABA

Indexed as

CuesAnimalsAssociation LearningAvoidance LearningBaclofenChoice BehaviorConditioning, PsychologicalConflict, PsychologicalGABA AgonistsMaleMotivationMuscimolNucleus AccumbensProto-Oncogene Proteins c-fosRats, Long-EvansReceptors, GABA-ABaclofenGABA AgonistsMuscimolProto-Oncogene Proteins c-fosReceptors, GABA-AReceptors, GABA-Bconditioned approachconditioned avoidancemotivationNAcpunishmentreward

Identifiers

PMID28275709
PMCPMC5309732

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.