ArticleAnnals of translational medicine2017
Hierarchical cluster analysis in clinical research with heterogeneous study population: highlighting its visualization with R.
Article in Annals of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Liver transplantation vs liver resection in HCC: promoting extensive collaborative research through a survival meta-analysis of meta-analyses.Frontiers in oncology · 2024Pooled it
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Plasma Glycosaminoglycans as Diagnostic and Prognostic Biomarkers in Surgically Treated Renal Cell Carcinoma.European urology oncology · 2018Trial
- Are similar nanoforms comparable in biodistribution? Data-driven approaches for optimizing nanomedicine design.Materials today. Nano · 2026Article
- Perioperative Metabolomic Profiling in Neonatal Cardiac Surgery Identifies a High-Risk Phenotype for Adverse Outcomes.JACC. Advances · 2026Article
- Identifying 20 homogeneous clusters of acute patients discharged with nonspecific diagnoses through k-prototypes mixed data clustering.BMC emergency medicine · 2026Observational
- Association between dietary patterns and the risk of breast cancer in South Asian countries: a protocol for a systematic review and meta-analysis of observational studies.BMJ public health · 2026Article
- Using ratings of perceived difficulty for balance exercise prescription and intensity progression.Frontiers in rehabilitation sciences · 2026Article
- Linking root length and surface area to yield: variety-specific root plasticity in winter wheat across contrasting European environments.Annals of botany · 2025Article
- Clustering environmental pollutants associated with increased risk of metabolic disease: a hierarchical analysis.Health information science and systems · 2025Article
- UQCRB regulates mitochondrial energy metabolism by promoting COX5 A in atherosclerotic endothelial dysfunction.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Article
- Long-term effects of multicomponent training on body composition and physical fitness in breast cancer survivors: a controlled study.Scientific reports · 2025Article
- The Composition of Volatile Organic Compounds Correlates with the Genetic Variability Within theMolecules (Basel, Switzerland) · 2025Article
- Evaluating the impact of view position in X-ray imaging for the classification of lung diseases.Physical and engineering sciences in medicine · 2025Article
- Hierarchical clustering analysis to inform classification of congenital malformations for surveillance of medication safety in pregnancy.American journal of epidemiology · 2025Article
- Influence of Sleep Quality on Recovery and Performance in Endurance and Ultra-Endurance Runners: Sex Differences Identified Through Hierarchical Clustering.Healthcare (Basel, Switzerland) · 2025Article
- Who attends a free sexual health center in Paris for HIV/STI screening? an observational study.BMC public health · 2025Observational
- Application of causal forests to randomised controlled trial data to identify heterogeneous treatment effects: a case study.BMC medical research methodology · 2025Article
- The Content of Volatile Organic Compounds inMolecules (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Big data clinical research typically involves thousands of patients and there are numerous variables available. Conventionally, these variables can be handled by multivariable regression modeling. In this article, the hierarchical cluster analysis (HCA) is introduced. This method is used to explore similarity between observations and/or clusters. The result can be visualized using heat maps and dendrograms. Sometimes, it would be interesting to add scatter plot and smooth lines into the panels of the heat map. The inherent R
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.