SynthesisNeuroImage. Clinical2017
Patients with schizophrenia show aberrant patterns of basal ganglia activation: Evidence from ALE meta-analysis.
Synthesis in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Shaky scaffolding: Age differences in cerebellar activation revealed through activation likelihood estimation meta-analysis.Human brain mapping · 2020Pooled it
- Whole brain grey matter synaptic terminal density, age and intellectual functioning in schizophrenia: an in vivo [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The indirect pathway hypothesis of schizophrenia: insights from perinatal asphyxia.Frontiers in physiology · 2026Review
- Quantification of motor abnormalities with instrumental tasks among adolescents with first-episode schizophrenia and depressive disorders.Scientific reports · 2025Article
- A Developmental Perspective on Early and Current Motor Abnormalities and Psychotic-Like Symptoms.Schizophrenia bulletin · 2025Article
- Track-Weighted Dynamic Functional Connectivity Profiles and Topographic Organization of the Human Pulvinar.Human brain mapping · 2024Article
- Effect of dual tasking on postural control in individuals with schizophrenia.Journal of musculoskeletal & neuronal interactions · 2023Article
- Age-related differences in functional network segregation in the context of sex and reproductive stage.Human brain mapping · 2023Article
- Normative model detects abnormal functional connectivity in psychiatric disorders.Frontiers in psychiatry · 2023Article
- Movement markers of schizophrenia: a detailed analysis of patients' gait patterns.European archives of psychiatry and clinical neuroscience · 2022Article
- Don't forget the little brain: A framework for incorporating the cerebellum into the understanding of cognitive aging.Neuroscience and biobehavioral reviews · 2022Review
- Dopamine transporter silencing in the rat: systems-level alterations in striato-cerebellar and prefrontal-midbrain circuits.Molecular psychiatry · 2022Article
- Ramping activity in the striatum.Frontiers in computational neuroscience · 2022Article
- Article
- Neural Substrates of the Drift-Diffusion Model in Brain Disorders.Frontiers in computational neuroscience · 2021Review
- Striatal and Thalamic Auditory Response During Deep Brain Stimulation for Essential Tremor: Implications for Psychosis.Neuromodulation : journal of the International Neuromodulation Society · 2020Article
- Intrinsic Connectivity of the Globus Pallidus: An Uncharted Marker of Functional Prognosis in People With First-Episode Schizophrenia.Schizophrenia bulletin · 2020Article
- Ketamine induced changes in regional cerebral blood flow, interregional connectivity patterns, and glutamate metabolism.Journal of psychiatric research · 2019Article
- Postural Sway Abnormalities in Schizotypal Personality Disorder.Schizophrenia bulletin · 2019Article
- Impaired Effective Connectivity During a Cerebellar-Mediated Sensorimotor Synchronization Task in Schizophrenia.Schizophrenia bulletin · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The diverse circuits and functional contributions of the basal ganglia, coupled with known differences in dopaminergic function in patients with schizophrenia, suggest they may be an important contributor to the etiology of the hallmark symptoms and cognitive dysfunction experienced by these patients. Using activation-likelihood-estimation meta-analysis of functional imaging research, we investigated differences in activation patterns in the basal ganglia in patients with schizophrenia, relative to healthy controls across task domains. This analysis included 42 functional neuroimaging studies, representing a variety of behavioral domains that have been linked to basal ganglia function in prior work. We provide important new information about the functional activation patterns and functional topography of the basal ganglia for different task domains in healthy controls. Crucially however, we demonstrate that across task domains, patients with schizophrenia show markedly decreased activation in the basal ganglia relative to healthy controls. Our results provide further support for basal ganglia dysfunction in patients with schizophrenia, and the broad dysfunction across task domains may contribute to the symptoms and cognitive deficits associated with schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.