ArticleFrontiers in behavioral neuroscience2017
Prefrontal Dopaminergic Mechanisms of Extinction in Adolescence Compared to Adulthood in Rats.
Article in Frontiers in behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 58 citations in OpenAlex.
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- Dopamine release and dopamine-related gene expression in the amygdala are modulated by the gastrin-releasing peptide in opposite directions during stress-enhanced fear learning and extinction.Molecular psychiatry · 2025Article
- Adolescent male and female rats show enhanced latent inhibition of conditioned fear compared to adult rats.Frontiers in behavioral neuroscience · 2025Article
- Fear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex.Translational psychiatry · 2024Article
- Associations between methamphetamine use disorder andDialogues in clinical neuroscience · 2024Article
- Intermixed safety cues facilitate extinction retention in adult and adolescent mice.Physiology & behavior · 2023Article
- Age-specific sex effects in extinction of conditioned fear in rodents.Frontiers in behavioral neuroscience · 2023Article
- Sex-dependent effects of chronic exercise on cognitive flexibility but not hippocampal Bdnf in aging mice.Neuronal signaling · 2022Review
- Involvement of D2-like dopaminergic receptors in contextual fear conditioning in female rats: influence of estrous cycle.Frontiers in behavioral neuroscience · 2022Article
- Long-term memory, synaptic plasticity and dopamine in rodent medial prefrontal cortex: Role in executive functions.Frontiers in behavioral neuroscience · 2022Review
- Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence.Neurobiology of stress · 2021Article
- Mesocorticolimbic Dopamine Pathways Across Adolescence: Diversity in Development.Frontiers in neural circuits · 2021Review
- Development-Dependent Plasticity in Vasoactive Intestinal Polypeptide Neurons in the Infralimbic Cortex.Cerebral cortex communications · 2021Article
- Prelimbic Cortical Stimulation Improves Spatial Memory Through Distinct Patterns of Hippocampal Gene Expression in Aged Rats.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
- Dopamine: from prediction error to psychotherapy.Translational psychiatry · 2020Review
- The Paradoxical Effect of Deep Brain Stimulation on Memory.Aging and disease · 2020Review
- Adolescent Vulnerability to Heightened Emotional Reactivity and Anxiety After Brief Exposure to an Obesogenic Diet.Frontiers in neuroscience · 2020Article
- Effects of Methamphetamine Exposure on Fear Learning and Memory in Adult and Adolescent Rats.Neurochemical research · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adolescents with anxiety disorders attain poorer outcomes following extinction-based treatment compared to adults. Extinction deficit during adolescence has been identified to involve immaturity in the medial prefrontal cortex (mPFC). Findings from adult rodents suggest extinction involves dopamine signaling in the mPFC. This system changes dramatically during adolescence, but its role in adolescent extinction is unknown. Therefore, we investigated the role of prefrontal dopamine in extinction using Pavlovian fear conditioning in adolescent and adult rats. Using quantitative PCR (qPCR) analyses, we measured changes in dopamine receptor gene expression in the mPFC before and after extinction. We then enhanced dopamine 1 receptor (D1R) or dopamine 2 receptor (D2R) signaling in the infralimbic cortex (IL) of the mPFC using agonists at the time of extinction. Adolescent rats displayed a deficit in extinction retention compared to adults. Extinction induced a reduction in D1R compared to D2R gene expression in adolescent rats, whereas an increase of D1R compared to D2R gene expression was observed in adult rats. Acutely enhancing IL D1R signaling using SKF-81297 had no effect on extinction at either age. In contrast, acutely enhancing IL D2R signaling with quinpirole significantly enhanced long-term extinction in adolescents, and impaired within-session extinction in adults. Our results suggest a dissociated role for prefrontal dopamine in fear extinction during adolescence compared to adulthood. Findings highlight the dopamine system as a potential pharmacological target to improve extinction-based treatments for adolescents.
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