ArticleFrontiers in molecular neuroscience2017
Mapping Gene Expression in Excitatory Neurons during Hippocampal Late-Phase Long-Term Potentiation.
Article in Frontiers in molecular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 71 citations in OpenAlex.
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- ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability.Nature chemical biology · 2026Article
- Distinct mechanisms of transcriptomic habituation to repeated stress in the mouse hippocampus.Nature communications · 2025Article
- Polyadenylation landscape of in vivo long-term potentiation in the rat brain.RNA (New York, N.Y.) · 2025Article
- Role of RNA-binding proteins in exercise-induced mRNA regulation: Unveiling biomarkers and therapeutic targets for schizophrenia.World journal of psychiatry · 2025Review
- The lncRNA Gas5 is an activity-responsive scaffold that mediates cAMP-dependent synaptic plasticity.Science signaling · 2025Article
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- Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation.bioRxiv : the preprint server for biology · 2025Article
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- Complementation testing identifies genes mediating effects at quantitative trait loci underlying fear-related behavior.Cell genomics · 2024Article
- The Intellectual Disability Risk GeneThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The integrated stress response effector GADD34 is repurposed by neurons to promote stimulus-induced translation.Cell reports · 2024Article
- The Association of Hippocampal Long-Term Potentiation-Induced Gene Expression with Genetic Risk for Psychosis.International journal of molecular sciences · 2024Article
- Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation.Nature communications · 2023Article
- Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation.Nature communications · 2023Article
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- Alzheimer's Disease beyond Calcium Dysregulation: The Complex Interplay between Calmodulin, Calmodulin-Binding Proteins and Amyloid Beta from Disease Onset through Progression.Current issues in molecular biology · 2023Review
- Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain.Journal of neurochemistry · 2023Review
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- eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance.iScience · 2023Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
The persistence of long-lasting changes in synaptic connectivity that underlie long-term memory require new RNA and protein synthesis. To elucidate the temporal pattern of gene expression that gives rise to long-lasting neuronal plasticity, we analyzed differentially-expressed (DE) RNAs in mouse hippocampal slices following induction of late phase long-term potentiation (L-LTP) specifically within pyramidal excitatory neurons using Translating Ribosome Affinity Purification RNA sequencing (TRAP-seq). We detected time-dependent changes in up- and down-regulated ribosome-associated mRNAs over 2 h following L-LTP induction, with minimal overlap of DE transcripts between time points. TRAP-seq revealed greater numbers of DE transcripts and magnitudes of LTP-induced changes than RNA-seq of all cell types in the hippocampus. Neuron-enriched transcripts had greater changes at the ribosome-loading level than the total RNA level, while RNA-seq identified many non-neuronal DE mRNAs. Our results highlight the importance of considering both time course and cell-type specificity in activity-dependent gene expression during memory formation.
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