Trial reportWorld journal of gastroenterology2017
Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: A clinical observation study.
Trial report in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Nitrate Enhances Gastric Mucosa Defense and Repair Process in Ethanol-Induced Gastric Ulcer Rats via the Notch-Tff2 Pathway.MedComm · 2026Article
- Pharmacological Mechanism ofMedicina (Kaunas, Lithuania) · 2023Article
- Trends inFrontiers in medicine · 2022Review
- Network Pharmacology and Molecular Docking Analysis on Pharmacological Mechanisms ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Do medicines commonly used by older adults impact their nutrient status?Exploratory research in clinical and social pharmacy · 2021Review
- Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats.Pharmaceutical biology · 2019Article
- Sex-specific effects ofWorld journal of gastroenterology · 2018Article
- The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality.
methodsForty-eight patients diagnosed with gastric ulcer between June 2014 and February 2016 were randomly allocated to the combination therapy group or monotherapy group. The former received hydrotalcite combined with esomeprazole, and the latter received esomeprazole alone, for 8 wk. Twenty-four healthy volunteers were recruited and acted as the healthy control group. Endoscopic ulcer healing was observed using white light endoscopy and narrow band imaging magnifying endoscopy. The composition of collagen fibers, amount of collagen deposition, expression of factor VIII and TGF-β1, and hydroxyproline content were analyzed by Masson staining, immunohistochemistry, immunofluorescent imaging and ELISA.
resultsFollowing treatment, changes in the gastric microvascular network were statistically different between the combination therapy group and the monotherapy group (
conclusionHydrotalcite combined with esomeprazole is superior to esomeprazole alone in improving gastric ulcer healing quality in terms of improving microvascular morphology, degree of structure maturity and function of regenerated mucosa.
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