ArticleHypertension research : official journal of the Japanese Society of Hypertension2017
The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Review
- Elabela is a reliable biomarker for predicting early onset preeclampsia: A comparative study.World journal of clinical cases · 2023Article
- Apelin as a Candidate for Hypertension Management; a Systematic Review and Meta-Analysis on Animal Studies.Archives of academic emergency medicine · 2022Review
- SIRT1 and Klotho expression in the heart and kidneys of rats with acute and chronic renovascular hypertension.Croatian medical journal · 2021Article
- Aplnr knockout mice display sex-specific changes in conditioned fear.Behavioural brain research · 2021Article
- Apelin/APJ system: A potential therapeutic target for endothelial dysfunction-related diseases.Journal of cellular physiology · 2019Review
- Renal denervation reduces sympathetic overactivation, brain oxidative stress, and renal injury in rats with renovascular hypertension independent of its effects on reducing blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Effect of apelin on cardiac contractility in acute reno-vascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization.Iranian journal of basic medical sciences · 2018Article
- Vascular effects of apelin: Mechanisms and therapeutic potential.Pharmacology & therapeutics · 2018Review
- The mechanism of all-Bioscience reports · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
The apelin/APJ system has an important role in the regulation of vascular tone and blood pressure. Opioid receptors (OPRs) are also important cardiovascular regulators and exert many of their effects by modulating the function of other G-protein-coupled receptors. The aim of this study was to analyze the interaction of apelin and the opioid system with respect to vascular responses to apelin in rats with renovascular hypertension (two-kidney, one clip (2K1C)). Homodynamic studies were carried out in 2K1C rats. Naloxone (a nonselective OPR inhibitor) or nor-binaltorphimine dihydrochloride (norBNI, a kappa OPR inhibitor) and signaling pathway inhibitors PTX (a Gi path inhibitor) and chelerythrine (a protein kinase C (PKC) inhibitor) were administered before apelin at 20 and 40 μg kg
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