SynthesisInternational journal of environmental research and public health2017
Lipoprotein Lipase (LPL) Polymorphism and the Risk of Coronary Artery Disease: A Meta-Analysis.
Synthesis in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Personalized Dietary Recommendations Based on Lipid-Related Genetic Variants: A Systematic Review.Frontiers in nutrition · 2022Pooled it
- Association between interleukin-8 gene -251 A/T polymorphism and the risk of coronary artery disease: A meta-analysis.Medicine · 2019Pooled it
- Association of HindIII Polymorphism of the Lipoprotein Lipase (LPL) Gene (rs320) and Plasma Metabolic Parameters in a Nigerian Population.Biochemical genetics · 2026Article
- Genetic Predictors of Psychosomatic Symptoms in Individuals with Metabolic Syndrome: Insights from a Cross-Sectional Study in Kazakhstan.International journal of environmental research and public health · 2025Article
- Article
- Article
- Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence.Biomedicines · 2022Review
- Genetic determinants of intracranial large artery stenosis in the northern Manhattan study.Journal of the neurological sciences · 2022Article
- Article
- Coronary Artery Disease: Association Study of 5 Loci with Angiographic Indices of Disease Severity.Disease markers · 2021Article
- Prognostic Implication of the Expression Level of PECAM-1 in Non-small Cell Lung Cancer.Frontiers in oncology · 2021Article
- The Role of Secretory Activity Molecules of Visceral Adipocytes in Abdominal Obesity in the Development of Cardiovascular Disease: A Review.Biomolecules · 2020Review
- Genetics, Dyslipidemia, and Cardiovascular Disease: New Insights.Current cardiology reports · 2019Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, the lipoprotein lipase (LPL) polymorphism has been extensively investigated as a potential risk factor for coronary artery disease (CAD). However, the results of these studies have been inconsistent. Therefore, we performed this meta-analysis to explore the association between LPL polymorphism and CAD risk.
methodsThe literature was searched from electronic databases such as Embase, China Biological Medicine Database, PubMed, Knowledge Infrastructure, and China National Web of Science by the key words "coronary artery disease", "lipoprotein lipase" and "polymorphism". All of the studies included in this manuscript met the inclusion and exclusion criteria. An odds ratio (OR) analysis using a 95% confidence interval (CI) was employed to assess the association of the LPL polymorphism with CAD susceptibility.
resultsWe performed a meta-analysis of 14 case-control studies including HindIII, Ser447X and PvuII polymorphism. A statistically significant increase in the risk of CAD was associated with LPL HindIII polymorphism. This included HindIII H⁺H⁺ genotype (OR = 1.28, 95% CI = 1.09-1.49,
conclusionsLPL HindIII polymorphism was significantly associated with the risk of CAD. For Ser447X polymorphism, it was found that only XX genotype was significantly associated with CAD risk. Furthermore, PvuII polymorphism had no significant association with CAD risk. It was considered that LPL HindIII polymorphism might serve as a potential biomarker for CAD risk.
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