Evidence map›Paper›PMID 28275196›Full record

ArticleJournal of virology2017

Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective.

S Boyoglu-Barnum, S O Todd, J Meng, T R Barnum, T Chirkova, L M Haynes, S J Jadhao, R A Tripp, A G Oomens, M L Moore and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

S Boyoglu-BarnumEmory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
S O ToddEmory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
J MengEmory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
T R BarnumUniversity of Georgia, Odum School of Ecology, Athens, Georgia, USA.
T ChirkovaEmory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
L M HaynesDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, Georgia, USA.
S J JadhaoEmory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
R A TrippUniversity of Georgia, Department of Infectious Diseases, Animal Health Research Center, Athens, Georgia, USA.
A G OomensDepartment of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, USA.
M L MooreEmory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
L J AndersonEmory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, Georgia, USA larry.anderson@emory.edu.
Emory University · USChildren's Healthcare of Atlanta · USUniversity of Georgia · USNational Center for Immunization and Respiratory Diseases · USOklahoma State University · US

Funding

Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dawn C Newcomb · 2011 to 2026
$34.9M
Training a New Generation of VaccinologistsT32AI074492 · NIAID · EMORY UNIVERSITY · PI Rama Rao Amara, Benjamin A Lopman · 2009 to 2026
$6.4M
Role of the Respiratory Syncytial Virus Fusion Protein in Airway Mucus InductionR01AI087798 · NIAID · EMORY UNIVERSITY · PI MOORE, MARTIN LAWRENCE · 2010 to 2014
$1.9M
Respiratory Syncytial Virus G proteins to improve safety/efficacy of vaccinesR21AI113385 · NIAID · EMORY UNIVERSITY · PI ANDERSON, LARRY J · 2015 to 2016
$429k
NIAID NIH HHS R01 AI087798NIAID NIH HHS R21 AI113385NIAID NIH HHS T32 AI074492NIAID NIH HHS U19 AI095227
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) belongs to the family

Indexed as

MutationAnimalsAntibodies, ViralChemokines, CX3CFemaleGTP-Binding ProteinsHumansImmunologic MemoryLungMiceMice, Inbred BALB CProtein Interaction Domains and MotifsRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus VaccinesTh1 CellsAntibodies, ViralChemokines, CX3CGTP-Binding ProteinsRespiratory Syncytial Virus VaccinesVaccines, AttenuatedCX3C motifG proteinslive attenuated vaccinesrespiratory syncytial virusvaccinesvirology

Identifiers

PMID28275196
PMCPMC5411601
OpenAlexW2594283277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.