ArticlePlant physiology2017
Identification of a Second Site of Pyrrolizidine Alkaloid Biosynthesis in Comfrey to Boost Plant Defense in Floral Stage
Article in Plant physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Roots of Indian heliotrope (Heliotropium indicum) produce simple pyrrolizidine alkaloids using the same homospermidine oxidase involved in biosynthesis of complex pyrrolizidine alkaloids in aerial parts.Plant biology (Stuttgart, Germany) · 2025Article
- Seeing double: two different homospermidine oxidases are involved in pyrrolizidine alkaloid biosynthesis in different organs of comfrey (Symphytum officinale).The Plant journal : for cell and molecular biology · 2024Article
- Pyrrolizidine alkaloids are synthesized and accumulated in flower of Myosotis scorpioides.Journal of plant research · 2024Article
- Healing of Skin Wounds in Rats Using Creams Based on Symphytum Officinale Extract.International journal of molecular sciences · 2024Article
- Review
- Anti-inflammatory Properties of the GenusIranian journal of pharmaceutical research : IJPR · 2022Review
- The long road of functional recruitment-The evolution of a gene duplicate to pyrrolizidine alkaloid biosynthesis in the morning glories (Convolvulaceae).Plant direct · 2022Article
- Insights into polyamine metabolism: homospermidine is double-oxidized in two discrete steps by a single copper-containing amine oxidase in pyrrolizidine alkaloid biosynthesis.The Plant cell · 2022Article
- Metabolic Toxification of 1,2-Unsaturated Pyrrolizidine Alkaloids Causes Human Hepatic Sinusoidal Obstruction Syndrome: The Update.International journal of molecular sciences · 2021Review
- CRISPR/Cas9-Mediated Genome Editing in Comfrey (Molecules (Basel, Switzerland) · 2021Article
- Article
- Review
- Specific Distribution of Pyrrolizidine Alkaloids in Floral Parts of Comfrey (Symphytum officinale) and its Implications for Flower Ecology.Journal of chemical ecology · 2019Article
- Pyrrolizidine Alkaloids: Biosynthesis, Biological Activities and Occurrence in Crop Plants.Molecules (Basel, Switzerland) · 2019Review
- Radioactive Tracer Feeding Experiments and Product Analysis to Determine the Biosynthetic Capability of Comfrey (Bio-protocol · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyrrolizidine alkaloids (PAs) are toxic secondary metabolites that are found in several distantly related families of the angiosperms. The first specific step in PA biosynthesis is catalyzed by homospermidine synthase (HSS), which has been recruited several times independently by duplication of the gene encoding deoxyhypusine synthase, an enzyme involved in the posttranslational activation of the eukaryotic initiation factor 5A. HSS shows highly diverse spatiotemporal gene expression in various PA-producing species. In comfrey (
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