ArticleJournal of immunology (Baltimore, Md. : 1950)2017
Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.
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Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
What it found
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Who cites it
34 citing papers in PubMed, 48 citations in OpenAlex.
- Sex hormones influence ORMDL3 expression: Implications for sex-associated asthma phenotype.The Journal of allergy and clinical immunology · 2026Article
- Article
- PGAP3 regulates human bronchial epithelial cell mRNAs present in asthma and respiratory virus reference data sets.medRxiv : the preprint server for health sciences · 2024Article
- Reticulons bind sphingolipids to activate the endoplasmic reticulum cell cycle checkpoint, the ER surveillance pathway.Cell reports · 2023Article
- The Crosstalk between FcεRI and Sphingosine Signaling in Allergic Inflammation.International journal of molecular sciences · 2022Review
- Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology.Nature communications · 2022Article
- Human Rhinovirus Infection of the Respiratory Tract Affects Sphingolipid Synthesis.American journal of respiratory cell and molecular biology · 2022Article
- Severe, but not moderate asthmatics share blood transcriptomic changes with post-traumatic stress disorder and depression.PloS one · 2022Article
- ORMDL3 overexpression facilitates FcεRI-mediated transcription of proinflammatory cytokines and thapsigargin-mediated PERK phosphorylation in RBL-2H3 cells.Immunity, inflammation and disease · 2021Article
- The Role of Sphingolipids in Allergic Disorders.Frontiers in allergy · 2021Review
- The Airway Epithelium-A Central Player in Asthma Pathogenesis.International journal of molecular sciences · 2020Review
- Increasing Sphingolipid Synthesis Alleviates Airway Hyperreactivity.American journal of respiratory cell and molecular biology · 2020Article
- Review
- Orosomucoid-like 3 Supports Rhinovirus Replication in Human Epithelial Cells.American journal of respiratory cell and molecular biology · 2020Article
- At last - linking ORMDL3 polymorphisms, decreased sphingolipid synthesis, and asthma susceptibility.The Journal of clinical investigation · 2020Article
- ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling.Frontiers in immunology · 2020Article
- Functional contribution of sphingosine-1-phosphate to airway pathology in cigarette smoke-exposed mice.British journal of pharmacology · 2020Article
- Give Me Some Room to Breathe! Can Targeting SPHK2 Reduce Airway Smooth Muscle Thickening in Asthma?American journal of respiratory cell and molecular biology · 2020Article
- ORMDL3 and Asthma: Linking Sphingolipid Regulation to Altered T Cell Function.Frontiers in immunology · 2020Review
- Metabolomics in the prevention and management of asthma.Expert review of respiratory medicine · 2019Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Marina MillerDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Arvin B TamDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.
James L MuellerDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Peter RosenthalDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Andrew BeppuDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Ruth GordilloTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-6533-2493
Matthew D McGeoughDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Christine VuongDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Taylor A DohertyDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Hal M HoffmanDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.
Maho NiwaDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.
David H BroideDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093; dbroide@ucsd.edu.
University of California San Diego · USThe University of Texas Southwestern Medical Center · US
Funding
TRM and airway inflammation and remodelingU19AI070535 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 2006 to 2025
$34.2MTRAINING IN MOLECULAR &CELL BIOLOGY OF ALLERGYT32AI007469 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 1994 to 2024
$6.9MFORESPORE ENGULFMENT DURING B SUBTILIS SPORULATIONR01GM057045 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POGLIANO, KIT J · 1998 to 2021
$6.1MRoles of the Unfolded Protein Response in Cell CycleR01GM087415 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maho R Niwa · 2010 to 2026
$5.5MChromosome 17q, allergic inflammation, and remodelingR01AI107779 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 2013 to 2024
$4.7MEosinophil trafficking and chronic tissue damage induced by allergic inflammationR37AI038425 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 2007 to 2016
$3.7MGSDMB and mucosal allergic responseR01AI124236 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 2017 to 2020
$2.4MRBM3 regulation of type 2 innate lymphoid cells in allergic inflammationR01AI114585 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOHERTY, TAYLOR A · 2015 to 2019
$2.3MEosinophil TraffickingR01AI038425 · NIAID · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI BROIDE, DAVID H · 1996 to 2005
$1.8MSiglec-F and Resolution of Allergic InflammationR01AI072115 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROIDE, DAVID H · 2008 to 2012
$1.7MNIAID NIH HHS R01 AI038425NIAID NIH HHS R01 AI072115NIAID NIH HHS R01 AI107779NIAID NIH HHS R01 AI114585NIAID NIH HHS R01 AI124236NIAID NIH HHS R37 AI038425NIAID NIH HHS T32 AI007469NIAID NIH HHS U19 AI070535NIGMS NIH HHS R01 GM057045NIGMS NIH HHS R01 GM087415
Abstract
In this study, we used cre-lox techniques to generate mice selectively deficient in ORMDL3 in airway epithelium (
Indexed as
AnimalsAsthmaDisease Models, AnimalLysophospholipidsMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutPolymerase Chain ReactionRespiratory HypersensitivitySphingosineLysophospholipidsMembrane ProteinsORMDL3 protein, mouseSphingosinesphingosine 1-phosphate
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.