Evidence map›Paper›PMID 28275077›Full record

ArticleJournal of clinical microbiology2017

Improving the Specificity of Plasmodium falciparum Malaria Diagnosis in High-Transmission Settings with a Two-Step Rapid Diagnostic Test and Microscopy Algorithm.

Moses Murungi, Travis Fulton, Raquel Reyes, Michael Matte, Moses Ntaro, Edgar Mulogo, Dan Nyehangane, Jonathan J Juliano, Mark J Siedner, Yap Boum and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Use of a Dual-Antigen Rapid Diagnostic Test to Screen Children for Severe Plasmodium falciparum Malaria in a High-Transmission, Resource-Limited Setting.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Observational
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Moses MurungiDepartment of Laboratory Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Travis FultonDivision of General Medicine & Clinical Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Raquel ReyesDivision of General Medicine & Clinical Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Michael MatteDepartment of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Moses NtaroDepartment of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Edgar MulogoDepartment of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Dan NyehanganeEpicentre Mbarara Research Centre, Mbarara, Uganda.
Jonathan J JulianoDivision of General Medicine & Clinical Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Mark J SiednerDepartment of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston Massachusetts, USA.
Yap BoumDepartment of Laboratory Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Ross M BoyceDivision of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA ross.boyce@unchealth.unc.edu.ORCID 0000-0002-9489-6324
Mbarara University of Science and Technology · UGUniversity of North Carolina at Chapel Hill · USEpicentre Uganda · UGHarvard University · US

Funding

Behavioral Aspects of Low-cost Medical Devices to Improve HIV CareK23MH099916 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2013 to 2017
$917k
Diversity and Phenotype of Artemisinin Resistance Mutations in Central AfricaR21AI121465 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, JONATHAN J · 2016 to 2017
$438k
NIAID NIH HHS R21 AI121465NIMH NIH HHS K23 MH099916
6 · The paper itself

Abstract

Poor specificity may negatively impact rapid diagnostic test (RDT)-based diagnostic strategies for malaria. We performed real-time PCR on a subset of subjects who had undergone diagnostic testing with a multiple-antigen (histidine-rich protein 2 and

Indexed as

AdolescentAdultAgedAlgorithmsAntigens, ProtozoanAntimalarialsArtemisininsChildDiagnostic Tests, RoutineFemaleHistidine-Rich GlycoproteinHumansMalaria, FalciparumMaleMicroscopyPlasmodium falciparumAntigens, ProtozoanAntimalarialsartemisininArtemisininsHistidine-Rich GlycoproteinHRP-2 antigen, Plasmodium falciparumProteinsProtozoan ProteinsRNA, Ribosomal, 18Santigen specificitydiagnosticsepidemiologymalariaPlasmodium falciparumrapid tests

Identifiers

PMID28275077
PMCPMC5405272
OpenAlexW2591923391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.