Evidence map›Paper›PMID 28275069›Full record

ArticleJournal of the American Heart Association2017

Atrial Arrhythmias and Electroanatomical Remodeling in Patients With Left Ventricular Assist Devices.

Amrish Deshmukh, Gene Kim, Martin Burke, Emeka Anyanwu, Valluvan Jeevanandam, Nir Uriel, Roderick Tung, Cevher Ozcan

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Liquid Biopsy in Endometriosis: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  3. Pooled it
  4. Article
  5. Observational
  6. Atrial fibrillation in continuous flow-left ventricular assist device (CF-LVAD) patients: impact on pathophysiology.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Review
  7. Article
  8. Drug therapy and catheter ablation for management of arrhythmias in continuous flow left ventricular assist device's patients: a Clinical Consensus Statement of the European Heart Rhythm Association and the Heart Failure Association of the ESC.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  9. Article
  10. Review
  11. Left Ventricular Assist Devices: A Primer For the General Cardiologist.Journal of the American Heart Association · 2022
    Review
  12. Article
  13. Review
  14. Preoperative atrial fibrillation predicts worse outcomes after LVAD implantation.Journal of cardiovascular and thoracic research · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Amrish DeshmukhDepartment of Medicine, University of Chicago, IL.
Gene KimDepartment of Medicine, University of Chicago, IL.
Martin BurkeDepartment of Medicine, University of Chicago, IL.
Emeka AnyanwuDepartment of Medicine, University of Chicago, IL.
Valluvan JeevanandamSection of Cardiac and Thoracic Surgery, University of Chicago, IL.
Nir UrielDepartment of Medicine, University of Chicago, IL.
Roderick TungDepartment of Medicine, University of Chicago, IL.
Cevher OzcanDepartment of Medicine, University of Chicago, IL cozcan@medicine.bsd.uchicago.edu.
University of Chicago · US

Funding

Mitochondrial Mechanisms and Novel Therapeutic Targets in Atrial FibrillationK08HL117082 · NHLBI · UNIVERSITY OF CHICAGO · PI OZCAN, CEVHER · 2014 to 2018
$798k
NHLBI NIH HHS K08 HL117082
6 · The paper itself

Abstract

backgroundThe incidence, predictors, and impact of atrial arrhythmias along with left atrial structural changes in patients with left ventricular assist devices (LVADs) remain undetermined. METHODS AND

resultsAll patients who underwent LVAD implantation from 2008 to 2015 at the University of Chicago Medical Center were included. Electronic medical records, electrocardiograms, echocardiograms, and cardiac electrical device interrogations were reviewed. The association of arrhythmias and clinical covariates with survival was evaluated by Kaplan-Meier and Cox proportional hazards analyses. A total of 331 patients were followed for a median of 330 days (range 0-2306 days). Mean age was 57.8±12.8 years, 256 participants (77.3%) were male, mean left ventricular ejection fraction was 20±6.6%, and 124 (37.5%) had ischemic cardiomyopathy. Atrial arrhythmias (53.8%) were highly prevalent and frequently coexisted before LVAD implantation: atrial fibrillation (AF) in 45.9%, atrial flutter in 13.9%, atrial tachycardia in 6.9%, and atrioventricular nodal reentrant tachycardia in 1.2%. New-onset AF was documented in 14 patients (7.8% of patients without prior AF) after the first 30 days with an LVAD. Increasing age, renal insufficiency, and lung disease were predictors of new-onset AF after LVAD implantation. Of patients with paroxysmal AF, 43% had no further AF after LVAD. Left atrial size and volume index improved with LVAD (

conclusionsAtrial arrhythmias are significantly prevalent in patients who require LVAD and are associated with increased mortality; however, LVADs induce favorable atrial structural and electrical remodeling.

Indexed as

Atrial RemodelingHeart-Assist DevicesAgedAge FactorsArrhythmias, CardiacAtrial FibrillationAtrial FlutterCardiomyopathiesCoronary Artery BypassEchocardiographyElectrocardiographyFemaleHeart FailureHumansHypoalbuminemiaKaplan-Meier Estimateatrial tachyarrhythmiaatriumleft ventricular assist deviceremodeling

Identifiers

PMID28275069
PMCPMC5524037
OpenAlexW2593953717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.