Evidence map›Paper›PMID 28275068›Full record

ArticleJournal of the American Heart Association2017

CCR7-CCL19/CCL21 Axis is Essential for Effective Arteriogenesis in a Murine Model of Hindlimb Ischemia.

A Yaël Nossent, Antonius J N M Bastiaansen, Erna A B Peters, Margreet R de Vries, Zeen Aref, Sabine M J Welten, Saskia C A de Jager, Tineke C T M van der Pouw Kraan, Paul H A Quax

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  9. Article
  10. Article
  11. Role of Vascular Smooth Muscle Cell Phenotype Switching in Arteriogenesis.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Proteomic changes in intracranial blood during human ischemic stroke.Journal of neurointerventional surgery · 2021
    Article
  14. Review
  15. Inflammation-Mediated Angiogenesis in Ischemic Stroke.Frontiers in cellular neuroscience · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. IRF3 and IRF7 mediate neovascularization via inflammatory cytokines.Journal of cellular and molecular medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

A Yaël NossentDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands a.y.nossent@lumc.nl.
Antonius J N M BastiaansenDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Erna A B PetersDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Margreet R de VriesDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Zeen ArefDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Sabine M J WeltenDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Saskia C A de JagerDivision of Biopharmaceutics, LACDR, Leiden University, Leiden, the Netherlands.
Tineke C T M van der Pouw KraanDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, the Netherlands.
Paul H A QuaxDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Leiden University Medical Center · NLAmsterdam UMC Location VUmc · NLLeiden University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn order to identify factors that stimulate arteriogenesis after ischemia, we followed gene expression profiles in two extreme models for collateral artery formation over 28 days after hindlimb ischemia, namely "good-responding" C57BL/6 mice and "poor-responding" BALB/c mice. METHODS AND

resultsAlthough BALB/c mice show very poor blood flow recovery after ischemia, most known proarteriogenic genes were upregulated more excessively and for a longer period than in C57BL/6 mice. In clear contrast, chemokine genes

conclusionsThese data show that CCR7-CCL19/CCL21 axis facilitates retention CD4

Indexed as

AnimalsCD4-Positive T-LymphocytesChemokine CCL19Chemokine CCL21Collateral CirculationGene ExpressionHindlimbIschemiaMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutNeovascularization, PhysiologicReceptors, CCR7Receptors, LDLCcl19 protein, mouseCcr7 protein, mouseChemokine CCL19Chemokine CCL21Receptors, CCR7Receptors, LDLarteriogenesisCCL19CCL21CCR7chemokinechemoreceptorhindlimb ischemiaperipheral artery disease

Identifiers

PMID28275068
PMCPMC5524034
OpenAlexW2594348848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.