ArticleJournal of neurophysiology2017
Differences in postinjury auditory system pathophysiology after mild blast and nonblast acute acoustic trauma.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Blast-Induced Auditory Injury: From Peripheral Pathology to Central Neurodegeneration.Iranian journal of otorhinolaryngology · 2026Review
- Sex Differences in Auditory Brainstem Responses of Two Rat Models of Autism: Environmental and Genetic Contributions to Autism-Like Auditory Function.Autism research : official journal of the International Society for Autism Research · 2025Article
- Rapid and objective assessment of auditory temporal processing using dynamic amplitude-modulated stimuli.Communications biology · 2024Article
- Mild Traumatic Brain Injury and the Auditory System: An Overview of the Mechanisms, Clinical Presentations, and Current Diagnostic Modalities.Journal of neurotrauma · 2024Review
- Characterization and closed-loop control of infrared thalamocortical stimulation produces spatially constrained single-unit responses.PNAS nexus · 2024Article
- Rapid and objective assessment of auditory temporal processing using dynamic amplitude-modulated stimuli.bioRxiv : the preprint server for biology · 2024Article
- Spatially specific, closed-loop infrared thalamocortical deep brain stimulation.bioRxiv : the preprint server for biology · 2023Article
- Effect of minocycline and its nano-formulation on central auditory system in blast-induced hearing loss rat model.Journal of otology · 2023Article
- Mitigation of Hearing Damage After Repeated Blast Exposures in Animal Model of Chinchilla.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- A Retrospective Study of the Effects of Traumatic Brain Injury on Auditory Function: From a Clinical Perspective.NeuroSci · 2022Article
- Correlation of Histomorphometric Changes with Diffusion Tensor Imaging for Evaluation of Blast-Induced Auditory Neurodegeneration in Chinchilla.Journal of neurotrauma · 2021Article
- Longitudinal auditory pathophysiology following mild blast-induced trauma.Journal of neurophysiology · 2021Article
- Psychosocial impairment following mild blast-induced traumatic brain injury in rats.Behavioural brain research · 2021Article
- Blast-induced hearing impairment in rats is associated with structural and molecular changes of the inner ear.Scientific reports · 2020Article
- The rat animal model for noise-induced hearing loss.The Journal of the Acoustical Society of America · 2019Review
- Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations.Scientific reports · 2018Article
- Effects of noise overexposure on tone detection in noise in nonhuman primates.Hearing research · 2018Article
- Age-related changes in envelope-following responses at equalized peripheral or central activation.Neurobiology of aging · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Hearing difficulties are the most commonly reported disabilities among veterans. Blast exposures during explosive events likely play a role, given their propensity to directly damage both peripheral (PAS) and central auditory system (CAS) components. Postblast PAS pathophysiology has been well documented in both clinical case reports and laboratory investigations. In contrast, blast-induced CAS dysfunction remains understudied but has been hypothesized to contribute to an array of common veteran behavioral complaints, including learning, memory, communication, and emotional regulation. This investigation compared the effects of acute blast and nonblast acoustic impulse trauma in adult male Sprague-Dawley rats. An array of audiometric tests were utilized, including distortion product otoacoustic emissions (DPOAE), auditory brain stem responses (ABR), middle latency responses (MLR), and envelope following responses (EFRs). Generally, more severe and persistent postinjury central auditory processing (CAP) deficits were observed in blast-exposed animals throughout the auditory neuraxis, spanning from the cochlea to the cortex. DPOAE and ABR results captured cochlear and auditory nerve/brain stem deficits, respectively. EFRs demonstrated temporal processing impairments suggestive of functional damage to regions in the auditory brain stem and the inferior colliculus. MLRs captured thalamocortical transmission and cortical activation impairments. Taken together, the results suggest blast-induced CAS dysfunction may play a complementary pathophysiological role to maladaptive neuroplasticity of PAS origin. Even mild blasts can produce lasting hearing impairments that can be assessed with noninvasive electrophysiology, allowing these measurements to serve as simple, effective diagnostics.
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