Evidence map›Paper›PMID 28275002›Full record

ArticleGenes & development2017

High constitutive activity of a broad panel of housekeeping and tissue-specific

Alessia Curina, Alberto Termanini, Iros Barozzi, Elena Prosperini, Marta Simonatto, Sara Polletti, Alessio Silvola, Monica Soldi, Liv Austenaa, Tiziana Bonaldi and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 87 citations in OpenAlex.

  1. Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Intracellular mono-ADP-ribosyltransferases at the host-virus interphase.Cellular and molecular life sciences : CMLS · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Alessia CurinaDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Alberto TermaniniHumanitas Clinical and Research Center, 20089 Rozzano-Milan, Italy.
Iros BarozziDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Elena ProsperiniDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Marta SimonattoDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Sara PollettiDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Alessio SilvolaDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Monica SoldiDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Liv AustenaaDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Tiziana BonaldiDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Serena GhislettiHumanitas Clinical and Research Center, 20089 Rozzano-Milan, Italy.
Gioacchino NatoliDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
European Institute of Oncology · ITHumanitas University · IT

Funding

European Research Council 692789
6 · The paper itself

Abstract

Enhancers and promoters that control the transcriptional output of terminally differentiated cells include cell type-specific and broadly active housekeeping elements. Whether the high constitutive activity of these two groups of

Indexed as

AnimalsChromatinEnhancer Elements, GeneticGene Expression RegulationGenes, EssentialMacrophagesMiceMice, Inbred C57BLPromoter Regions, GeneticProtein BindingProtein TransportTranscription FactorsChromatinTranscription FactorsenhancersETShousekeeping genesmacrophagestranscription

Identifiers

PMID28275002
PMCPMC5358759
OpenAlexW2591728940

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.