Evidence map›Paper›PMID 28274991›Full record

ArticleJournal of leukocyte biology2017

Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222.

Ziwen Zhu, Duo Zhang, Heedoo Lee, Aravind Ajakumar Menon, Jingxuan Wu, Kebin Hu, Yang Jin

Abstract read
In one paragraph

Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 104 citations in OpenAlex.

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  14. Ghost messages: cell death signals spread.Cell communication and signaling : CCS · 2023
    Review
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ziwen ZhuDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, Massachusetts, USA.
Duo ZhangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, Massachusetts, USA.
Heedoo LeeDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, Massachusetts, USA.
Aravind Ajakumar MenonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, Massachusetts, USA.
Jingxuan WuDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, Massachusetts, USA.
Kebin HuDepartment of Cellular and Molecular Physiology and Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Yang JinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, Massachusetts, USA; yjin1@bu.edu.
Boston University · USPennsylvania State University · US

Funding

Cross talk between cav-1 and flot1 in lung injuryR01HL102076 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI JIN, YANG · 2011 to 2015
$2.1M
p90 Ribosomal S6 Kinase and Chronic Kidney DiseaseR01DK102624 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HU, KEBIN · 2014 to 2018
$1.5M
Mechanistic insights into the systemic inflammation and organ failure in sepsisR01GM111313 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI JIN, YANG · 2014 to 2017
$1.3M
Development of the RNA molecule-enriched, cell type-specific exosomesR21AI121644 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JIN, YANG · 2016 to 2017
$444k
NHLBI NIH HHS R01 HL102076NIAID NIH HHS R21 AI121644NIDDK NIH HHS R01 DK102624NIGMS NIH HHS R01 GM111313
6 · The paper itself

Abstract

Bacterial pneumonia is a common and serious clinical entity. Alveolar epithelial cells and alveolar macrophages are the first line of defense in the innate immunity against bacterial pathogens. Epithelial cells are known to release chemokines/cytokines that recruit and activate phagocytic cells. However, the signals sent from alveolar macrophages back to the lung epithelial cells remain largely unexplored. We found that LPS, a well-recognized stimulator derived from gram-negative (G

Indexed as

Cell ProliferationAnimalsCell-Derived MicroparticlesCells, CulturedExosomesExtracellular VesiclesHumansLungMacrophages, AlveolarMaleMiceMice, Inbred C57BLMicroRNAsMicroRNAsMIRN221 microRNA, mouseMIRN222 microRNA, mousebacterial pneumoniaextracellular vesiclelung cancer

Identifiers

PMID28274991
PMCPMC5433853
OpenAlexW2592843746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.