Evidence map›Paper›PMID 28274961›Full record

ArticleJournal of lipid research2017

Lipid and lipoprotein abnormalities in acute lymphoblastic leukemia survivors.

Sophia Morel, Jade Leahy, Maryse Fournier, Benoit Lamarche, Carole Garofalo, Guy Grimard, Floriane Poulain, Edgard Delvin, Caroline Laverdière, Maja Krajinovic and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Metabolic Implications of Childhood Cancer.Current pediatrics reports · 2025
    Article
  7. Article
  8. Article
  9. The evolving landscape of PCSK9 inhibition in cancer.European journal of pharmacology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Metabolic differences among newborns born to mothers with a history of leukemia or lymphoma.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022
    Article
  14. Article
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  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Sophia MorelResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Jade LeahyResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Maryse FournierResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Benoit LamarcheInstitute of Nutrition and Functional Foods, Laval University, Quebec, Quebec, Canada G1V 0A6.
Carole GarofaloResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Guy GrimardDepartment of Pediatrics, Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Floriane PoulainResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Edgard DelvinResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Caroline LaverdièreResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Maja KrajinovicResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Simon DrouinResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Daniel SinnettResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Valérie MarcilResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5.
Emile LevyResearch Centre, Sainte-Justine University Hospital Health Center Université de Montréal, Montreal, Quebec, Canada H3T 1C5 emile.levy@recherche-ste-justine.qc.ca.
Centre Hospitalier Universitaire Sainte-Justine · CAUniversité de Montréal · CAUniversité Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Survivors of acute lymphoblastic leukemia (ALL), the most common cancer in children, are at increased risk of developing late cardiometabolic conditions. However, the mechanisms are not fully understood. This study aimed to characterize the plasma lipid profile, Apo distribution, and lipoprotein composition of 80 childhood ALL survivors compared with 22 healthy controls. Our results show that, despite their young age, 50% of the ALL survivors displayed dyslipidemia, characterized by increased plasma triglyceride (TG) and LDL-cholesterol, as well as decreased HDL-cholesterol. ALL survivors exhibited lower plasma Apo A-I and higher Apo B-100 and C-II levels, along with elevated Apo C-II/C-III and B-100/A-I ratios. VLDL fractions of dyslipidemic ALL survivors contained more TG, free cholesterol, and phospholipid moieties, but less protein. Differences in Apo content were found between ALL survivors and controls for all lipoprotein fractions except HDL

Indexed as

Cancer SurvivorsApolipoproteins EDyslipidemiasFemaleHumansLipoprotein LipaseLipoproteinsMalePolymorphism, GeneticPrecursor Cell Lymphoblastic Leukemia-LymphomaReceptors, LDLYoung AdultApolipoproteins ELipoprotein LipaseLipoproteinsLPL protein, humanReceptors, LDLapolipoproteinsatherosclerosiscancercardiovascular diseasesclinical studiesdyslipidemialipid and lipoprotein metabolismmetabolic syndrome

Identifiers

PMID28274961
PMCPMC5408606
OpenAlexW2593685779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.