ArticleAmerican journal of physiology. Renal physiology2017
Endothelial dysfunction correlates with exaggerated exercise pressor response during whole body maximal exercise in chronic kidney disease.
Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Pooled it
- The impact of exercise on physical function, cardiovascular outcomes and quality of life in chronic kidney disease patients: a systematic review.International urology and nephrology · 2018Pooled it
- Lower vascular conductance responses to handgrip exercise are improved following acute antioxidant supplementation in young individuals with post-traumatic stress disorder.Experimental physiology · 2024Trial
- Peak oxygen consumption is positively associated with estimates of oxygen extraction and microvascular blood volume in veterans with chronic kidney disease.American journal of physiology. Renal physiology · 2026Article
- Autonomic control of the vasculature in CKD: leveraging renal denervation.Frontiers in neuroscience · 2026Review
- Race and sex differences in pressor response to laboratory stressors in patients with chronic kidney disease.American journal of physiology. Renal physiology · 2025Article
- Exercise pressor reflex function is augmented in rats with chronic kidney disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Sympathetic transduction to blood pressure in patients with chronic kidney disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Evaluation of MicroRNA 145 and MicroRNA 155 as Markers of Cardiovascular Risk in Chronic Kidney Disease.Cureus · 2024Article
- Hemodynamic and neuromuscular basis of reduced exercise capacity in patients with end-stage renal disease.European journal of applied physiology · 2024Article
- Is It Possible to Train the Endothelium?-A Narrative Literature Review.Life (Basel, Switzerland) · 2024Review
- Exercise for patients with chronic kidney disease: from cells to systems to function.American journal of physiology. Renal physiology · 2024Review
- Differences in peripheral microcirculatory blood flow regulation in chronic kidney disease based on wavelet analysis of resting near-infrared spectroscopy.Microvascular research · 2024Article
- Neurocirculatory regulation and adaptations to exercise in chronic kidney disease.American journal of physiology. Heart and circulatory physiology · 2023Review
- Call for Papers: Exercise and the kidneys in health and disease.American journal of physiology. Renal physiology · 2023Article
- Clinical and Prognostic Value of Exaggerated Blood Pressure Response to Exercise.Reviews in cardiovascular medicine · 2023Review
- The exercise pressor reflex: An update.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases.Journal of cardiovascular translational research · 2022Review
- Aerobic exercise training improves endothelial function and attenuates blood pressure reactivity during maximal exercise in chronic kidney disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Fatigability and the Role of Neuromuscular Impairments in Chronic Kidney Disease.American journal of nephrology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Chronic kidney disease (CKD) patients have exercise intolerance associated with increased cardiovascular mortality. Previous studies demonstrate that blood pressure (BP) and sympathetic nerve responses to handgrip exercise are exaggerated in CKD. These patients also have decreased nitric oxide (NO) bioavailability and endothelial dysfunction, which could potentially lead to an impaired ability to vasodilate during exercise. We hypothesized that CKD patients have exaggerated BP responses during maximal whole body exercise and that endothelial dysfunction correlates with greater exercise pressor responses in these patients. Brachial artery flow-mediated dilation (FMD) was assessed before maximal treadmill exercise in 56 participants: 38 CKD (56.7 ± 1.2 yr old, 38 men) and 21 controls (52.8 ± 1.8 yr old, 20 men). During maximal treadmill exercise, the slope-of-rise in systolic BP (+10.32 vs. +7.75 mmHg/stage,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.