ArticleNeurobiology of learning and memory2017
Extinction after fear memory reactivation fails to eliminate renewal in rats.
Article in Neurobiology of learning and memory, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Fear attenuation collaborations to optimize translation.Behavioral neuroscience · 2024Article
- Carbon Dioxide Reactivity Differentially Predicts Fear Expression After Extinction and Retrieval-Extinction in Rats.Biological psychiatry global open science · 2024Article
- Reconsolidation and Fear Extinction: An Update.Current topics in behavioral neurosciences · 2023Article
- Unrelenting Fear Under Stress: Neural Circuits and Mechanisms for the Immediate Extinction Deficit.Frontiers in systems neuroscience · 2022Review
- A proposed mechanism for the MDMA-mediated extinction of traumatic memories in PTSD patients treated with MDMA-assisted therapy.Frontiers in psychiatry · 2022Review
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- GluN2B and GluN2A-containing NMDAR are differentially involved in extinction memory destabilization and restabilization during reconsolidation.Scientific reports · 2021Article
- Molecular and circuit mechanisms regulating cocaine memory.Cellular and molecular life sciences : CMLS · 2020Review
- No persistent attenuation of fear memories in humans: A registered replication of the reactivation-extinction effect.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Decreased cued fear discrimination learning in female rats as a function of estrous phase.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Common neurocircuitry mediating drug and fear relapse in preclinical models.Psychopharmacology · 2019Review
- Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.Psychopharmacology · 2019Review
- An Additional Prior Retrieval Alters the Effects of a Retrieval-Extinction Procedure on Recent and Remote Fear Memory.Frontiers in behavioral neuroscience · 2017Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Retrieving fear memories just prior to extinction has been reported to effectively erase fear memories and prevent fear relapse. The current study examined whether the type of retrieval procedure influences the ability of extinction to impair fear renewal, a form of relapse in which responding to a conditional stimulus (CS) returns outside of the extinction context. Rats first underwent Pavlovian fear conditioning with an auditory CS and footshock unconditional stimulus (US); freezing behavior served as the index of conditioned fear. Twenty-four hours later, the rats underwent a retrieval-extinction procedure. Specifically, 1h prior to extinction (45 CS-alone trials; 44 for rats receiving a CS reminder), fear memory was retrieved by either a single exposure to the CS alone, the US alone, a CS paired with the US, or exposure to the conditioning context itself. Over the next few days, conditional freezing to the extinguished CS was tested in the extinction and conditioning context in that order (i.e., an ABBA design). In the extinction context, rats that received a CS+US trial before extinction exhibited higher levels of conditional freezing than animals in all other groups, which did not differ from one another. In the renewal context, all groups showed renewal, and none of the reactivation procedures reduced renewal relative to a control group that did not receive a reactivation procedure prior to extinction. These data suggest retrieval-extinction procedures may have limited efficacy in preventing fear renewal.
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