ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017
Sugary beverage intake and preclinical Alzheimer's disease in the community.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- The Impact of Free and Added Sugars on Cognitive Function: A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- Dietary pattern in relation to the risk of Alzheimer's disease: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- The Importance of the World Health Organization Sugar Guidelines for Dental Health and Obesity Prevention.Caries research · 2019Guideline
- Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.Clinical nutrition (Edinburgh, Scotland) · 2022Trial
- A high-glycemic diet is associated with cerebral amyloid burden in cognitively normal older adults.The American journal of clinical nutrition · 2017Trial
- A clinically practical aging clock (physical clock) for healthy aging: development, validation, and application for health assessment and intervention.Science China. Life sciences · 2026Article
- Associations of Individual Beverage Types and Substitution with Dementia Risk: A UK Biobank Cohort Study.The journal of nutrition, health & aging · 2026Article
- Cognitive and neuroanatomical effects of chronic high-fructose corn syrup consumption in the aging rat brain.BMC neuroscience · 2025Article
- Dietary sugar intake, genetic susceptibility, and risk of dementia: A prospective cohort study.The journal of prevention of Alzheimer's disease · 2025Article
- Sugar Alcohols as Crosslinking Delay Additives for Fracturing Fluids.Gels (Basel, Switzerland) · 2025Article
- Effects of nutritional counseling on dietary patterns in patients with mild cognitive impairment: insights from the BrainFit-Nutrition study.Frontiers in nutrition · 2025Article
- Dietary Sugar Intake Associated with a Higher Risk of Dementia in Community-Dwelling Older Adults.Journal of Alzheimer's disease : JAD · 2023Article
- Healthy Lifestyle, Genetic Risk and Brain Health: A Gene-Environment Interaction Study in the UK Biobank.Nutrients · 2022Article
- Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis.Nutrients · 2022Article
- Dietary Regulation of Gut-Brain Axis in Alzheimer's Disease: Importance of Microbiota Metabolites.Frontiers in neuroscience · 2021Review
- High Glycemic Diet Is Related to Brain Amyloid Accumulation Over One Year in Preclinical Alzheimer's Disease.Frontiers in nutrition · 2021Article
- Adherence to Healthy Diet Can Delay Alzheimer's Diseases Development: A Systematic Review and Meta-Analysis.Preventive nutrition and food science · 2020Review
- High Glycemic Load Is Associated with Cognitive Decline in Apolipoprotein E ε4 Allele Carriers.Nutrients · 2020Article
- Uric Acid and Hypertension: An Update With Recommendations.American journal of hypertension · 2020Review
- Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer's Disease.Frontiers in aging neuroscience · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionExcess sugar consumption has been linked with Alzheimer's disease (AD) pathology in animal models.
methodsWe examined the cross-sectional association of sugary beverage consumption with neuropsychological (N = 4276) and magnetic resonance imaging (N = 3846) markers of preclinical Alzheimer's disease and vascular brain injury (VBI) in the community-based Framingham Heart Study. Intake of sugary beverages was estimated using a food frequency questionnaire.
resultsRelative to consuming less than one sugary beverage per day, higher intake of sugary beverages was associated with lower total brain volume (1-2/day, β ± standard error [SE] = -0.55 ± 0.14 mean percent difference, P = .0002; >2/day, β ± SE = -0.68 ± 0.18, P < .0001), and poorer performance on tests of episodic memory (all P < .01). Daily fruit juice intake was associated with lower total brain volume, hippocampal volume, and poorer episodic memory (all P < .05). Sugary beverage intake was not associated with VBI in a consistent manner across outcomes. DISCUSSION: Higher intake of sugary beverages was associated cross-sectionally with markers of preclinical AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.