ReviewTrends in cognitive sciences2017
Pediatric Irritability: A Systems Neuroscience Approach.
Review in Trends in cognitive sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 96 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dose-Response Relationship and Pharmacokinetics of Intranasal Oxytocin on Neural Impact in Youth With High Levels of Irritability
Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model
A Mechanistic Examination of Continuous Cycle Oral Contractive Administration in Binge Eating
Who cites it
96 citing papers in PubMed, 4 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Systematic Review and Meta-Analysis: Early Irritability as a Transdiagnostic Neurodevelopmental Vulnerability to Later Mental Health Problems.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Pooled it
- Pharmacological and non-pharmacological interventions for irritability in autism spectrum disorder: a systematic review and meta-analysis with the GRADE assessment.Molecular autism · 2024Pooled it
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- Clarifying the role of Cortico-Cortical and Amygdalo-Cortical brain dysconnectivity associated with Conduct Problems.NeuroImage. Clinical · 2023Pooled it
- Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability.The American journal of psychiatry · 2024Trial
- Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Associations and mechanisms between childhood adversity and irritability or trait anger across the lifespan: A systematic review and meta-analysis.Journal of mood and anxiety disorders · 2026Review
- Midfrontal theta power relates to response speeding following frustrative nonreward.NeuroImage · 2026Article
- Anxiety-depression symptom networks across emotion regulation profiles in Chinese nurses: a latent profile and network analysis.BMC nursing · 2026Article
- Exploring Transdiagnostic Mechanisms of Youth Externalizing Psychopathology: A Longitudinal Person-Centered Approach.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Locus-Coeruleus Norepinephrine Functioning as a Predictor of Childhood Mental Health (LOCUS-MENTAL): Protocol for a Longitudinal Study.JMIR research protocols · 2026Article
- Sensitivity and Bias in Face-Emotion Labeling: Replication and Extension to Youth With Irritability and Anxiety.JAACAP open · 2026Article
- Inhibition-related connectivity predicts irritability risk and resilience across early adolescence.Social cognitive and affective neuroscience · 2026Article
- Evaluating psychometric validity of ecological momentary assessment for youth irritability.Journal of affective disorders · 2025Article
- The relationship between irritability and suicidal ideation: the chain mediating effects of rumination and distress tolerance.BMC psychiatry · 2025Article
- Article
- Neural mechanisms of reward processing in preadolescent irritability: Insights from the ABCD study.Journal of affective disorders · 2025Article
- Oxytocin treatment rescues irritability-like behavior in Cc2d1a conditional knockout mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neural mechanisms of inhibitory control in preadolescent irritability: Insights from the ABCD study.Biological psychology · 2024Article
- Adolescent anxiety and depression: perspectives of network analysis and longitudinal network analysis.BMC psychiatry · 2024Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Irritability, defined as an increased propensity to exhibit increased anger relative to one's peers, is a common clinical problem in youth. Irritability can be conceptualized as aberrant responses to frustration (where frustration is the emotional response to blocked goal attainment) and/or aberrant 'approach' responses to threat. Irritable youth show hyper-reactivity to threat mediated by dysfunction in amygdala, medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), insula, striatum, and association cortex. Irritable youth also show abnormalities in reward learning, cognitive control, and responses to frustration. These abnormalities are mediated by circuitry that includes the inferior frontal gyrus (iFG), striatum, ACC, and parietal cortex. Effective treatments for irritability are lacking, but pathophysiological research could lead to more precisely targeted interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.