Evidence map›Paper›PMID 28274637›Full record

ArticleVaccine2017

Immunoglobulin GM and KM genes and measles vaccine-induced humoral immunity.

Inna G Ovsyannikova, Beth R Larrabee, Daniel J Schaid, Gregory A Poland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Introduction.Vaccine · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Inna G OvsyannikovaMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
Beth R LarrabeeDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Daniel J SchaidDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Gregory A PolandMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: poland.gregory@mayo.edu.
Mayo Clinic in Florida · US

Funding

The Immunogenetics of Measles ImmunityR01AI033144 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 1993 to 2022
$8.1M
Immunogenetic Mechanisms of Vaccine ResponseR37AI048793 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2011 to 2020
$5.4M
IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSER01AI048793 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2001 to 2010
$4.3M
Understanding measles vaccine failure (and success) in Southern IndiaR01AI121054 · NIAID · MAYO CLINIC ROCHESTER · PI JACOB, JOSHY, KENNEDY, RICHARD B · 2017 to 2021
$3.8M
Genetic Markers of Long-Term Mumps Vaccine ImmunityR01AI127365 · NIAID · MAYO CLINIC ROCHESTER · PI KENNEDY, RICHARD B · 2016 to 2020
$3.6M
NIAID NIH HHS HHSN272201000025CNIAID NIH HHS N01 AI040065NIAID NIH HHS R01 AI033144NIAID NIH HHS R01 AI048793NIAID NIH HHS R01 AI121054NIAID NIH HHS R01 AI127365NIAID NIH HHS R37 AI048793
6 · The paper itself

Abstract

Identifying genetic polymorphisms that explain variations in humoral immunity to live measles virus vaccine is of great interest. Immunoglobulin GM (heavy chain) and KM (light chain) allotypes are genetic markers known to be associated with susceptibility to several infectious diseases. We assessed associations between GM and KM genotypes and measles vaccine humoral immunity (neutralizing antibody titers) in a combined cohort (n=1796) of racially diverse healthy individuals (age 18-41years). We did not discover any significant associations between GM and/or KM genotypes and measles vaccine-induced neutralizing antibody titers. African-American subjects had higher neutralizing antibody titers than Caucasians (1260mIU/mL vs. 740mIU/mL, p=7.10×10

Indexed as

AdultAntibodies, NeutralizingAntibodies, ViralBlack or African AmericanCohort StudiesFemaleGenotypeHumansImmunity, HumoralImmunoglobulin Gm AllotypesImmunoglobulin Km AllotypesMaleMeaslesMeasles VaccineMeasles virusVaccinationAntibodies, NeutralizingAntibodies, ViralImmunoglobulin Gm AllotypesImmunoglobulin Km AllotypesMeasles VaccineAntibodiesGenetic association studiesImmunoglobulin allotypesImmunoglobulin Gm allotypesImmunoglobulin Km allotypesImmunoglobulinsMeaslesMeasles-Mumps-Rubella vaccineMeasles vaccineMeasles virusNeutralizing

Identifiers

PMID28274637
PMCPMC5587382
OpenAlexW2592903106

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.