Evidence map›Paper›PMID 28274559›Full record

Trial reportThe Journal of thoracic and cardiovascular surgery2017

A novel technique for tumor localization and targeted lymphatic mapping in early-stage lung cancer.

Krista J Hachey, Christopher S Digesu, Katherine W Armstrong, Denis M Gilmore, Onkar V Khullar, Brian Whang, Hisashi Tsukada, Yolonda L Colson

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in The Journal of thoracic and cardiovascular surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Intraoperative Molecular Imaging of Lung Cancer: A Review.Surgical oncology clinics of North America · 2022
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Sentinel lymph node biopsy for lung cancer.General thoracic and cardiovascular surgery · 2020
    Review
  14. [Advances of Electromagnetic Navigation Bronchoscopy for Peripheral Pulmonary Lesions].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020
    Review
  15. Article
  16. Review
  17. Article
  18. Carinal resection.Shanghai chest · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Krista J HacheyDivision of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass.
Christopher S DigesuDivision of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass.
Katherine W ArmstrongDivision of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass.
Denis M GilmoreDivision of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass; Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tenn.
Onkar V KhullarDivision of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass; Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Ga.
Brian WhangDivision of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass.
Hisashi TsukadaDivision of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass.
Yolonda L ColsonDivision of Thoracic Surgery, Brigham and Women's Hospital, Boston, Mass. Electronic address: ycolson@partners.org.
Brigham and Women's Hospital · US

Funding

ADVANCED TRAINING IN SURGICAL ONCOLOGYT32CA009535 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BUENO, RAPHAEL · 1985 to 2015
$3.5M
NIR Imaging of Sentinel Nodes in Lung Cancer: Finding MicrometastasesR01CA131044 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI COLSON, YOLONDA L · 2008 to 2011
$1.5M
NCI NIH HHS R01 CA131044NCI NIH HHS T32 CA009535
6 · The paper itself

Abstract

objectiveTo investigate safety and feasibility of navigational bronchoscopy (NB)-guided near-infrared (NIR) localization of small, ill-defined lung lesions and sentinel lymph nodes (SLN) for accurate staging in patients with non-small cell lung cancer (NSCLC).

methodsPatients with known or suspected stage I NSCLC were enrolled in a prospective pilot trial for lesion localization and SLN mapping via NB-guided NIR marking. Successful localization, SLN detection rates, histopathologic status of SLN versus overall nodes, and concordance to initial clinical stage were measured. Ex vivo confirmation of NIR

resultsTwelve patients underwent NB-guided marking with indocyanine green of lung lesions ranging in size from 0.4 to 2.2 cm and located 0.1 to 3 cm from the pleural surface. An NIR

conclusionsNB-guided NIR lesion localization and SLN identification was safe and feasible. This minimally invasive image-guided technique may permit the accurate localization and nodal staging of early stage lung cancers.

Indexed as

Indocyanine GreenSpectroscopy, Near-InfraredBronchoscopyCarcinoma, Non-Small-Cell LungColoring AgentsFeasibility StudiesFemaleHumansLung NeoplasmsLymphatic MetastasisLymph NodesMaleMiddle AgedPilot ProjectsProspective StudiesSensitivity and SpecificityColoring AgentsIndocyanine Greenlung cancernavigational bronchoscopynear-infraredsentinel lymph nodetumor localization

Identifiers

PMID28274559
PMCPMC5552457
OpenAlexW2586610631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.