ArticleThe Journal of thoracic and cardiovascular surgery2017
Morbidity and mortality prediction in pediatric heart surgery: Physiological profiles and surgical complexity.
Article in The Journal of thoracic and cardiovascular surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03455218 (Nitric Oxide Administration During Pediatric Cardiopulmonary Bypass Surgery to Prevent Platelet activation-a Single Center Pilot Study), which is not on this map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nitric Oxide Administration During Pediatric Cardiopulmonary Bypass Surgery to Prevent Platelet activation-a Single Center Pilot Study
Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Why stop at extubation?-the difference between enhanced recovery and on table extubation after paediatric cardiac surgery.Translational pediatrics · 2026Review
- Article
- Epidemiology of children and adolescents undergoing surgery at Mexican public hospitals: a retrospective registry-based analysis from 2010 to 2022.BMC pediatrics · 2026Article
- Management and Imaging Strategies in Pediatric Infective Endocarditis With Mitral Prolapse.JACC. Case reports · 2026Article
- Development and validation of a nomogram for predicting prolonged ICU stays after pediatric cardiac surgery.World journal of emergency medicine · 2025Article
- Automated integration of multi-slice spatial transcriptomics data in 2D and 3D using VR-Omics.Genome biology · 2025Article
- Short-term outcomes and risk factors for mortality in neonatal cardiac surgeries with cardiopulmonary bypass: a 5-year single-center report.World journal of pediatric surgery · 2025Article
- Case Report: Percoronary device occlusion of right coronary artery fistula into left ventricle in an infant.Frontiers in cardiovascular medicine · 2025Article
- Intensive Care Unit Analgosedation After Cardiac Surgery in Children with Williams Syndrome : a Matched Case-Control Study.Pediatric cardiology · 2024Article
- Comparison of Three Different Multiple Organ Dysfunction Scores for Predicting Mortality after Neonatal Cardiac Surgery.Children (Basel, Switzerland) · 2023Article
- Health Care Policy and Congenital Heart Disease: 2020 Focus on Our 2030 Future.Journal of the American Heart Association · 2021Article
- Long-Term Outcome of PICU Patients Discharged With New, Functional Status Morbidity.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2021Article
- Association Between Preoperative Factors and In-hospital Mortality in Neonates After Cardiac Surgery in China.Frontiers in pediatrics · 2021Article
- Post-operative discharge education for parent caregivers of children with congenital heart disease: a needs assessment.Cardiology in the young · 2020Article
- The Compensatory Reserve Index Responds to Acute Hemodynamic Changes in Patients with Congenital Heart Disease: A Proof of Concept Study.Pediatric cardiology · 2020Article
- Functional deficit in children with congenital heart disease undergoing surgical correction after intensive care unit discharge.Revista Brasileira de terapia intensiva · 2020Article
- Pulmonary Vein Stenosis: Outcomes in Children With Congenital Heart Disease and Prematurity.Seminars in thoracic and cardiovascular surgery · 2019Article
- Morbidity: Changing the Outcome Paradigm for Pediatric Critical Care.Pediatric clinics of North America · 2017Review
- Brazilian version of the Pediatric Functional Status Scale: translation and cross-cultural adaptation.Revista Brasileira de terapia intensivaArticle
- Complicaciones relacionadas con el cateterismo cardíaco pediátrico y cardiopatías congénitas.Archivos de cardiologia de MexicoObservational
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesOutcome prediction for pediatric heart surgery has focused on mortality but mortality has been significantly reduced over the past 2 decades. Clinical care practices now emphasize reducing morbidity. Physiology-based profiles assessed by the Pediatric Risk of Mortality (PRISM) score are associated with new significant functional morbidity detected at hospital discharge. Our aims were to assess the relationship between new functional morbidity and surgical risk categories (Risk Adjustment for Congenital Heart Surgery [RACHS] and Society for Thoracic Surgery Congenital Heart Surgery Database Mortality Risk [STAT]), measure the performance of 3-level (intact survival, survival with new functional morbidity, or death) and 2-level (survival or death) PRISM prediction algorithms, and assess whether including RACHS or STAT complexity categories improves the PRISM predictive performance.
methodsPatients (newborn to age 18 years) were randomly selected from 7 sites (December 2011-April 2013). Morbidity (using the Functional Status Scale) and mortality were assessed at hospital discharge. The most recently published PRISM algorithms were tested for goodness of fit, and discrimination with and without the RACHS and STAT complexity categories.
resultsThe mortality rate in the 1550 patients was 3.2%. Significant new functional morbidity rate occurred in 4.8%, increasing from 1.8% to 13.9%, 1.7%, and 12.9% from the lowest to the highest RACHS and STAT categories, respectively. The 3-level and 2-level PRISM models had satisfactory goodness of fit and substantial discriminative ability. Inclusion of RACHS and STAT complexity categories did not improve model performance.
conclusionsBoth mortality and new, functional morbidity are important outcomes associated with surgical complexity and can be predicted using PRISM algorithms. Adding surgical complexity to the physiologic profiles does not improve predictor performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.