ArticleEnvironmental health : a global access science source2017
Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis.
Article in Environmental health : a global access science source, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Maternal Phthalate Exposure and Allergic Diseases in Children: A Meta-Analysis and Network Toxicology.International journal of molecular sciences · 2025Pooled it
- What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review.The British journal of dermatology · 2020Pooled it
- Network Toxicology and Machine Learning Uncover BPA-Driven Molecular Mechanisms in Atopic Dermatitis.Current issues in molecular biology · 2026Article
- Identifying key molecular interactions and pathways linking DEHP and its metabolite MEHP to allergic rhinitis: a network toxicology and molecular dynamics study.BMC pharmacology & toxicology · 2026Article
- An online program focusing on modifiable lifestyle and environmental interventions was associated with improved pediatric eczema symptoms: results from a retrospective observational study.Frontiers in allergy · 2026Article
- Prenatal Exposure to Phthalates, Bisphenols and Their Mixtures and Early Childhood Allergic Conditions and Asthma: Results from the APrON Cohort.International journal of environmental research and public health · 2025Article
- Association of prenatal exposure to phthalates with risks of asthma, wheeze, and allergic diseases during childhood: a systematic review and meta-analysis.Journal of environmental health science & engineering · 2025Article
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
- Plastics in dermatology: A review and solutions.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Review
- Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium.Environmental pollution (Barking, Essex : 1987) · 2025Article
- The impact of perfumes and cosmetic products on human health: a narrative review.Frontiers in toxicology · 2025Review
- The association between environmental endocrine-disrupting chemicals and allergic disorders in children: A comprehensive systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- A review of pharmaceutical and personal care products and atopic dermatitis based on epidemiological and basic research findings.Frontiers in public health · 2025Review
- Non-Target Screening of Chemicals in Selected Cotton Products by GC/MS and Their Safety Assessment.Molecules (Basel, Switzerland) · 2024Article
- Spatial modeling connecting childhood atopic dermatitis prevalence with household exposure to pollutants.Communications medicine · 2024Article
- Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis.International journal of molecular sciences · 2024Article
- Regulatory T Cell-Targeted Immunomodulatory Therapy for Long-Term Clinical Improvement of Atopic Dermatitis: Hypotheses and Perspectives.Life (Basel, Switzerland) · 2023Review
- The Detrimental Effects of Phthalates on Allergic Diseases.Allergy, asthma & immunology research · 2022Article
- The Role of Di(2-Ethylhexyl) Phthalate as an Exacerbating Factor in Chronic Spontaneous Urticaria.Allergy, asthma & immunology research · 2022Article
- Association between Urinary Phthalate Metabolite Concentration and Atopic Dermatitis in Korean Adolescents Participating in the Third Korean National Environmental Health Survey, 2015-2017.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite increasing evidence on the relationship between exposure to phthalates and bisphenol A with allergies and asthma, reports on atopic dermatitis (AD) with these chemicals are few. We assessed the association between AD symptoms and the exposure to phthalates and bisphenol A and in children.
methodsWe surveyed 18 boys with AD (age 3-7 years) in a day care center in Seoul between May 2009 and April 2010. AD symptoms were recorded by using a daily symptom diary. We collected 460 series of pooled urine twice a day, in the morning and afternoon, over 230 working days and measured the concentrations of mono-2-ethyl-5-oxohexyl phthalate (5-oxo-MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (5-OH-MEHP), mono-isobutyl phthalate (MnBP) and bisphenol A glucuronide (BPAG) in the pooled urine. Logistic regression was used for statistical analysis.
resultsMost phthalate metabolite levels were higher in the morning than in the afternoon (p < 0.0001). There was seasonal variation in the levels of phthalates and bisphenol A metabolites. Levels of 5-OH-MEHP, MnBP, and BPAG were highest in summer (p < 0.0001). Manifestation of AD symptoms was associated with an increase in urinary levels of MnBP (adjusted odds ratio, aOR = 2.85, 95% CI: 1.12-7.26 per 1 μg/L of MnBP) and BPAG (aOR = 1.79, 95% CI: 0.91-3.52 per 1 μg/L BPAG) on the same day. The levels of MnBP and BPAG in the previous day increased AD symptoms (aOR = 2.74, 95% CI: 1.21-6.20, for 1 μg/L of MnBP and aOR = 2.01, 95% CI: 1.08-3.74 for 1 μg/L BPAG).
conclusionOur results suggest that exposure to phthalates and bisphenol A is associated with aggravation of AD symptoms in children.
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