ArticleBMC complementary and alternative medicine2017
Effect of microbial siderophores on mammalian non-malignant and malignant cell lines.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Optimization, characterization and biological activity of siderophore produced by marine Streptomyces coelicolor.PloS one · 2026Article
- Metagenomic analyses reveal E. coli-derived siderophores as potential signatures for breast cancer.Journal of translational medicine · 2025Article
- Mechanistic insights into gut microbe derived siderophores and PHD2 interactions with implications for HIF-1α stabilization.Scientific reports · 2025Article
- A Practical Toolkit for the Detection, Isolation, Quantification, and Characterization of Siderophores and Metallophores in Microorganisms.ACS omega · 2024Review
- Opportunities and challenges of microbial siderophores in the medical field.Applied microbiology and biotechnology · 2023Review
- Induction of Iron Stress in Hepatocellular Carcinoma Cell Lines by Siderophore of Aspergillus nidulans Towards Promising Anticancer Effect.Biological trace element research · 2022Article
- Perspective on the biotechnological production of bacterial siderophores and their use.Applied microbiology and biotechnology · 2022Review
- Understanding the Potential and Risk of Bacterial Siderophores in Cancer.Frontiers in oncology · 2022Review
- Recent developments in siderotyping: procedure and application.World journal of microbiology & biotechnology · 2020Review
- Bioactivity of Serratiochelin A, a Siderophore Isolated from a Co-Culture ofMicroorganisms · 2020Article
- Enterobactin, an iron chelating bacterial siderophore, arrests cancer cell proliferation.Biochemical pharmacology · 2019Article
- Activity of siderophores against drug-resistant Gram-positive and Gram-negative bacteria.Infection and drug resistance · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment.
methodsIn the present study, we have evaluated effect of three siderophores - exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay.
resultsThese siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells.
conclusionsBased on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies.
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Registered trials
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