Trial reportBMC cancer2017
Redefining radiotherapy for early-stage breast cancer with single dose ablative treatment: a study protocol.
Trial report in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02316561 (Single Dose Ablative Preoperative Radiation Treatment for Early-Stage Breast Cancer in Elderly Patients), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Single Dose Ablative Preoperative Radiation Treatment for Early-Stage Breast Cancer in Elderly Patients
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Definitive single-fraction ablative radiotherapy for early-stage breast cancer: DESERT-I trial - a dose-escalation study protocol.Radiation oncology (London, England) · 2026Article
- Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors.Translational oncology · 2025Article
- Preoperative partial breast radiation for favorable early-stage breast cancer: a narrative review.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025Review
- Magnetic resonance imaging-guided single-fraction preoperative radiotherapy for early-stage breast cancer (the RICE trial): feasibility study.Pilot and feasibility studies · 2024Article
- Treatment Options for Early Stage Inoperable Breast Cancer: Cryoablation or Radiotherapy?Breast care (Basel, Switzerland) · 2024Review
- A narrative review for radiation oncologists to implement preoperative partial breast irradiation.La Radiologia medica · 2023Review
- Definitive ablative stereotactic partial breast irradiation in early stage inoperable breast cancer.Journal of cancer research and clinical oncology · 2023Article
- Adaptive radiotherapy for breast cancer.Clinical and translational radiation oncology · 2023Review
- Radiotherapy of early-stage breast cancer.Precision radiation oncology · 2023Review
- Single fraction ablative preoperative radiation treatment for early-stage breast cancer: the CRYSTAL study - a phase I/II clinical trial protocol.BMC cancer · 2022Article
- Multi-parametric MRI (mpMRI) for treatment response assessment of radiation therapy.Medical physics · 2022Article
- Ultra-Short Fraction Schedules as Part of De-intensification Strategies for Early-Stage Breast Cancer.Annals of surgical oncology · 2021Review
- MRI-Guided Radiation Therapy.Advances in oncology · 2021Article
- The many facets of Notch signaling in breast cancer: toward overcoming therapeutic resistance.Genes & development · 2020Review
- Tumour response 3 months after neoadjuvant single-fraction radiotherapy for low-risk breast cancer.Current oncology (Toronto, Ont.) · 2020Article
- Optimizing MR-Guided Radiotherapy for Breast Cancer Patients.Frontiers in oncology · 2020Review
- RF-PCA: A New Solution for Rapid Identification of Breast Cancer Categorical Data Based on Attribute Selection and Feature Extraction.Frontiers in genetics · 2020Article
- Accuracy and efficiency of image-guided radiation therapy (IGRT) for preoperative partial breast radiosurgery.Journal of radiosurgery and SBRT · 2020Article
- Single dose partial breast irradiation using an MRI linear accelerator in the supine and prone treatment position.Clinical and translational radiation oncology · 2019Article
- Establishing the Role of Stereotactic Ablative Body Radiotherapy in Early-Stage Breast Cancer.International journal of breast cancer · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA shift towards less burdening and more patient friendly treatments for breast cancer is currently ongoing. In low-risk patients with early-stage disease, accelerated partial breast irradiation (APBI) is an alternative for whole breast irradiation following breast-conserving surgery. MRI-guided single dose ablative APBI has the potential to offer a minimally burdening, non-invasive treatment that could replace current breast-conserving therapy.
methodsThe ABLATIVE study is a prospective, single arm, multicenter study evaluating preoperative, single dose, ablative radiation treatment in patients with early-stage breast cancer. Patients with core biopsy proven non-lobular invasive breast cancer, (estrogen receptor positive, Her2 negative, maximum tumor size 3.0 cm on diagnostic MRI) and a negative sentinel node biopsy are eligible. Radiotherapy (RT) planning will be performed using a contrast enhanced (CE) planning CT-scan, co-registered with a CE-MRI, both in supine RT position. A total of twenty-five consecutive patients will be treated with a single ablative RT dose of 20 Gy to the tumor and 15 Gy to the tumorbed. Follow-up MRIs are scheduled within 1 week, 2, 4 and 6 months after single-dose RT. Breast-conserving surgery is scheduled at six months following RT. Primary study endpoint is pathological complete response. Secondary study endpoints are the radiological response and toxicity. Furthermore, patients will fill out questionnaires on quality of life and functional status. Cosmetic outcome will be evaluated by the treating radiation oncologist, patient and 'Breast Cancer Conservation Treatment cosmetic results' software. Recurrence and survival rates will be assessed. The patients will be followed up to 10 years after diagnosis. If patients give additional informed consent, a biopsy and a part of the irradiated specimen will be stored at the local Biobank and used for future research on radiotherapy response associated genotyping. DISCUSSION: The ABLATIVE study evaluates MRI-guided single dose ablative RT in patients with early-stage breast cancer, aiming at a less burdening and non-invasive alternative for current breast-conserving treatment.
trial registrationClinicalTrials.gov registration number NCT02316561 . The trial was registrated prospectively on October 10th 2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.