ArticleBMC evolutionary biology2017
Comprehensive transcriptomic analysis of Tibetan Schizothoracinae fish Gymnocypris przewalskii reveals how it adapts to a high altitude aquatic life.
Article in BMC evolutionary biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 91 citations in OpenAlex.
- Complete Mitochondrial Genome and Phylogenetic Analysis of the Chungtien Schizothoracin (Current issues in molecular biology · 2026Article
- Altitude-Related Adaptation in Freshwater Snails (Animals : an open access journal from MDPI · 2026Article
- Genetic and Haplotype Diversity ofAnimals : an open access journal from MDPI · 2026Article
- Schizothoracinae in Plateau River Networks: Drainage History, Polyploid Genome Evolution, Multi-Omics Evidence Chains, and Conservation Units.Animals : an open access journal from MDPI · 2026Review
- Protective role of nano-selenium on Gymnocypris przewalskii under saline-alkaline stress: a comprehensive analysis of transcriptomics and metabolomics.Fish physiology and biochemistry · 2026Article
- Genome-wide insights into adaptive divergence, historical demography, and habitat suitability of Ptychobarbus Kaznakovi and P. leptosomus.BMC genomics · 2026Article
- Article
- Genomic-based revelation of genetic structure and adaptive characterization of Schizopygopsis malacanthus in the Jinsha River and Yalong River.BMC genomics · 2025Article
- Transcriptomics and proteomics provide insights into the adaptative strategies of Tibetan naked carps (Gymnocypris przewalskii) to saline-alkaline variations.BMC genomics · 2025Article
- Dynamic Outlier Slicing Allows Broader Exploration of Adaptive Divergence: A Comparison of Individual Genome and Pool-Seq Data Linked to Humic Adaptation in Perch.Molecular ecology · 2025Article
- Gut microbiota: a new frontier in understanding and protecting endangered plateau schizothorax fish.Frontiers in microbiology · 2025Article
- Developmental plasticity of the cardiovascular system in oviparous vertebrates: effects of chronic hypoxia and interactive stressors in the context of climate change.The Journal of experimental biology · 2024Review
- Article
- Transcriptomic and proteomic analyses provide insights into the adaptive responses to the combined impact of salinity and alkalinity in Gymnocypris przewalskii.Bioresources and bioprocessing · 2022Article
- Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation inFrontiers in genetics · 2022Article
- Characterization and complexity of transcriptome in Gymnocypris przewalskii using single-molecule long-read sequencing and RNA-seq.DNA research : an international journal for rapid publication of reports on genes and genomes · 2021Article
- Genomic Signature of Shifts in Selection and Alkaline Adaptation in Highland Fish.Genome biology and evolution · 2021Article
- Chromosomal genome of Triplophysa bleekeri provides insights into its evolution and environmental adaptation.GigaScience · 2020Article
- Prevalence and genetic diversity of Echinorhynchus gymnocyprii (Acanthocephala: Echinorhynchidae) in schizothoracine fishes (Cyprinidae: Schizothoracinae) in Qinghai-Tibetan Plateau, China.Parasites & vectors · 2020Article
- Comparative Genomics Identifies Putative Signatures of Sociality in Spiders.Genome biology and evolution · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding the genetic basis of adaptation to high altitude life is of paramount importance for preserving and managing genetic diversity in highland animals. This objective has been addressed mainly in terrestrial fauna but rarely in aquatic animals. Tibetan Schizothoracinae fish is the ideal model system in evolutionary biology, carrying key insights into evolutionary genetics of speciation and adaptation at high altitude. Gymnocypris przewalskii is the newly formed Schizothoracinae fish species in the Tibetan Plateau, inhabits chronic cold, extreme saline and alkaline aquatic environment in Lake Qinghai, thus evolving the unique genomic signatures to adapt extremely severe environments.
resultsTo characterize its genomic features, we assembled de novo transcriptome of G. przewalskii from Lake Qinghai. Intriguingly, by comparative genomic analyses of G. przewalskii and 8 other fish species, we identified potential expansions in gene families related to energy metabolism, transport and developmental functions, possibly underlying the adaptation to these environmental stresses. Through comprehensive molecular evolution analyses, we found that sets of genes controlling mitochondrion, ion homoeostasis, acid-base balance and innate immunity show significant signals of positive selection. Compared to previous studies on highland fishes, we failed to identify any positively selected genes related to hypoxia response.
conclusionsOur findings provide comprehensive insights into the genetic basis of teleost fish that underlie their adaptation to extreme high altitude aquatic life on the Tibetan Plateau.
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