ArticleJournal of clinical and diagnostic research : JCDR2017
Role of Glutathione S-Transferase in Coronary Artery Disease Patients with and Without Type 2 Diabetes Mellitus.
Article in Journal of clinical and diagnostic research : JCDR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.Frontiers in genetics · 2022Pooled it
- Constitutive expression of cardiomyocyte Klf9 precipitates metabolic dysfunction and spontaneous cardiomyopathy.Cellular signalling · 2025Article
- The role of glutathione S-transferases in human disease pathogenesis and their current inhibitors.Genes & diseases · 2025Review
- Cardioprotective Role of Swertiamarin, a Plant Glycoside Against Experimentally Induced Myocardial Infarction via Antioxidant and Anti-inflammatory Functions.Applied biochemistry and biotechnology · 2023Article
- Association of Genetic and Allelic Variants of Von Willebrand Factor (VWF), Glutathione S-Transferase and Tumor Necrosis Factor Alpha with Ischemic Stroke Susceptibility and Progression in the Saudi Population.Life (Basel, Switzerland) · 2023Article
- Migraine-Associated Mutation in the Na,K-ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function.Journal of the American Heart Association · 2022Article
- Controlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy.Scientific reports · 2021Article
- Glutathione S-transferases gene polymorphism influence on the age of diabetes type 2 onset.BMJ open diabetes research & care · 2020Article
- Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats.Interdisciplinary toxicology · 2017Article
Corrections and comments
- Erratum issuedCorrection.2018
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGlutathione S - transferase (GST) is an important enzyme in detoxification and helps in lowering oxidative stress. It is speculated that this enzyme is induced under conditions of oxidative stress as a protective mechanism.
aimTo evaluate the status of Glutathione S-transferase in Coronary artery disease patients with and without type 2 Diabetes mellitus. MATERIALS AND
methodsThe study was conducted in the Department of Biotechnology, Swami Satyanand College of Management and Technology in collaboration with Department of Biochemistry, Govt Medical College Amritsar. A total of 133 diagnosed cases of Coronary Artery Disease (CAD) were selected from the OPD and Medicine Ward of a private hospital, Amritsar. CAD patients were segregated into two groups i.e., group-1 and group-2 on the basis if they had Type 2 Diabetes mellitus or not. A total of 110 ages and sex matched healthy individuals were taken as controls from the general population. Written informed consent was obtained from all the subjects. All the subjects were investigated for serum GST activity, Total antioxidant status, plasma GSH levels, serum MDA and lipid profile.
resultsSerum GST activity was significantly high (p<0.05) in CAD patients as compared to controls. CAD patients having Type 2 Diabetes had more raised serum GST activity, indicating marked oxidative stress in these patients. This was supported from the observation that serum MDA levels were also significantly (p<0.05) high in CAD patients with Type 2 Diabetes mellitus. Total antioxidant status was significantly depressed (p<0.05) in CAD patients whether diabetic or non-diabetic as compared to controls. No significant difference (p>0.05) in plasma GSH levels were observed between CAD patients and controls. Age and sex related variations in serum GST activity were insignificant (p>0.05).
conclusionIncreased serum GST activity in CAD patients especially with Type 2 Diabetes is suggestive of a protective mechanism to combat increased oxidative stress which was reflected by raised serum MDA level and depressed total antioxidant status in patient group. However, whether this effect is a short term or long term, a separate follow up study is required.
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