ArticleScientific reports2017
Arterial graft with elastic layer structure grown from cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Mechanosensitive Stanniocalcin-1 Suppresses Smooth Muscle Cell Proliferation and Attenuates Experimental Pulmonary Hypertension.Circulation research · 2026Article
- Tunable Bioresorbable Scaffolds With Marine Sulfated Polysaccharides for Small-Caliber Vascular Grafts: A Multi-Layered Strategy Combining Electrospinning and 4-Axis Printing.Advanced healthcare materials · 2026Article
- Development of High-Cell-Density Tissue Method for Compressed Modular Bioactuator.Micromachines · 2022Article
- The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections.European journal of clinical investigation · 2022Review
- Designing Cardiovascular Implants Taking in View the Endothelial Basement Membrane.International journal of molecular sciences · 2021Review
- Human iPS Cell-derived Tissue Engineered Vascular Graft: Recent Advances and Future Directions.Stem cell reviews and reports · 2021Review
- Bio-assembling and Bioprinting for Engineering Microvessels from the Bottom Up.International journal of bioprinting · 2021Review
- Challenges and Possibilities of Cell-Based Tissue-Engineered Vascular Grafts.Cyborg and bionic systems (Washington, D.C.) · 2021Review
- On-Chip Cell Incubator for Simultaneous Observation of Culture with and without Periodic Hydrostatic Pressure.Micromachines · 2019Article
- Tissue Engineering at the Blood-Contacting Surface: A Review of Challenges and Strategies in Vascular Graft Development.Advanced healthcare materials · 2018Review
- Building Blood Vessels with Vascular Progenitor Cells.Trends in molecular medicine · 2018Review
- Hydrostatic pressure suppresses fibrotic changes via Akt/GSK-3 signaling in human cardiac fibroblasts.Physiological reports · 2018Article
- LED-CT Scan for pH Distribution on a Cross-Section of Cell Culture Medium.Sensors (Basel, Switzerland) · 2018Article
- Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats.Cell transplantationArticle
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shortage of autologous blood vessel sources and disadvantages of synthetic grafts have increased interest in the development of tissue-engineered vascular grafts. However, tunica media, which comprises layered elastic laminae, largely determines arterial elasticity, and is difficult to synthesize. Here, we describe a method for fabrication of arterial grafts with elastic layer structure from cultured human vascular SMCs by periodic exposure to extremely high hydrostatic pressure (HP) during repeated cell seeding. Repeated slow cycles (0.002 Hz) between 110 and 180 kPa increased stress-fiber polymerization and fibronectin fibrillogenesis on SMCs, which is required for elastic fiber formation. To fabricate arterial grafts, seeding of rat vascular SMCs and exposure to the periodic HP were repeated alternatively ten times. The obtained medial grafts were highly elastic and tensile rupture strength was 1451 ± 159 mmHg, in which elastic fibers were abundantly formed. The patch medial grafts were sutured at the rat aorta and found to be completely patent and endothelialized after 2.5 months, although tubular medial constructs implanted in rats as interpositional aortic grafts withstood arterial blood pressure only in early acute phase. This novel organized self-assembly method would enable mass production of scaffold-free arterial grafts in vitro and have potential therapeutic applications for cardiovascular diseases.
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