ArticleScientific reports2017
Chronic exposure to low doses of estradiol-17ß increases blood pressure in young female rats: A possible role for central Endothelin-1.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Effects of Puberty on Blood Pressure Trajectories - Underlying Processes.Current hypertension reports · 2023Review
- Fever Induced by Zymosan A and Polyinosinic-Polycytidylic Acid in Female Rats: Influence of Sex Hormones and the Participation of Endothelin-1.Inflammation · 2021Article
- Immune-mediated febrile response in female rats: Role of central hypothalamic mediators.Scientific reports · 2020Article
- Phenylethanol Glycosides Protect Myocardial Hypertrophy Induced by Abdominal Aortic Constriction via ECE-1 Demethylation Inhibition and PI3K/PKB/eNOS Pathway Enhancement.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Chronic estradiol exposure - harmful effects on behavior, cardiovascular and reproductive functions.Reproduction (Cambridge, England) · 2018Review
- 17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity.Neurotoxicology · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Previously, we demonstrated that chronic exposure to low levels of estradiol-17β (E2) increases mean arterial pressure (MAP) in young female Sprague-Dawley (SD) rats, however, the underlying mechanisms are unclear. Since endothelin-1 (ET-1) is implicated in blood pressure (BP) regulation, we hypothesized that E2's effects on MAP are mediated through central ET-1. To test this, young female SD rats were either sham implanted or implanted s.c. with slow-release E2 pellets (20 ng/day for 90 days). BP was monitored by telemetry. After 75 days of E2 exposure, ET
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