ArticleScientific reports2017
Infection with koala retrovirus subgroup B (KoRV-B), but not KoRV-A, is associated with chlamydial disease in free-ranging koalas (Phascolarctos cinereus).
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Current status and future directions ofFrontiers in veterinary science · 2026Pooled it
- Investigating the association between koala retrovirus and primary bone neoplasia in koalas (Veterinary pathology · 2026Article
- Development and Validation of a Standardised Genomic Tool for Conservation Management of the Koala (Animals : an open access journal from MDPI · 2025Article
- The relationships of viral and protozoal co-infections to Chlamydia pecorum infection and chlamydiosis outcomes in northern koalas (Phascolarctos cinereus).PLoS pathogens · 2025Article
- Elevated oncogene expressions in koala infected with multiple koala retrovirus subtypes: a preliminary study.Virus genes · 2025Article
- Temporal dynamics of koala retrovirus plasma RNA load in relation to faecal glucocorticoid metabolites and Chlamydia infection.The Journal of general virology · 2025Article
- A high frequency of detection of koala retrovirus fragments in Victorian koalas suggests historic integration of KoRV.The Journal of general virology · 2025Article
- Koala MHCII association with chlamydia infertility remains equivocal: a need for new research approaches.Scientific reports · 2024Article
- A preliminary study of gene expression changes in Koalas Infected with Koala Retrovirus (KoRV) and identification of potential biomarkers for KoRV pathogenesis.BMC veterinary research · 2024Article
- The Utility of the Koala Scat: A Scoping Review.Biology · 2024Article
- Expanding the known distribution of phascolartid gammaherpesvirus 1 in koalas to populations across Queensland and New South Wales.Scientific reports · 2024Article
- GALV-KoRV-related retroviruses in diverse Australian and African rodent species.Virus evolution · 2024Article
- Investigation of koala retrovirus in captive koalas with pneumonia and comparative analysis of subtype distribution.Archives of virology · 2023Article
- Milk Transmission of Mammalian Retroviruses.Microorganisms · 2023Review
- Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas.PLoS pathogens · 2022Article
- Article
- Koala retrovirus genetic diversity and transmission dynamics within captive koala populations.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Single Cell Cryo-Soft X-ray Tomography Shows That EachLife (Basel, Switzerland) · 2021Article
- Phylogenetic and geographical analysis of a retrovirus during the early stages of endogenous adaptation and exogenous spread in a new host.Molecular ecology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The virulence of chlamydial infection in wild koalas is highly variable between individuals. Some koalas can be infected (PCR positive) with Chlamydia for long periods but remain asymptomatic, whereas others develop clinical disease. Chlamydia in the koala has traditionally been studied without regard to coinfection with other pathogens, although koalas are usually subject to infection with koala retrovirus (KoRV). Retroviruses can be immunosuppressive, and there is evidence of an immunosuppressive effect of KoRV in vitro. Originally thought to be a single endogenous strain, a new, potentially more virulent exogenous variant (KoRV-B) was recently reported. We hypothesized that KoRV-B might significantly alter chlamydial disease outcomes in koalas, presumably via immunosuppression. By studying sub-groups of Chlamydia and KoRV infected koalas in the wild, we found that neither total KoRV load (either viraemia or proviral copies per genome), nor chlamydial infection level or strain type, was significantly associated with chlamydial disease risk. However, PCR positivity with KoRV-B was significantly associated with chlamydial disease in koalas (p = 0.02961). This represents an example of a recently evolved virus variant that may be predisposing its host (the koala) to overt clinical disease when co-infected with an otherwise asymptomatic bacterial pathogen (Chlamydia).
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